National Toxicology Program

National Toxicology Program

Testing Status of Pyrogallol - M960044


CASRN: 87-66-1

Formula: C6-H6-O3

Synonyms/Common Names

  • 1,2,3-Benzenetriol (9CI)
  • Pyrogallic acid
  • 1,2,3-Trihydroxybenzene

Known Uses

Naturally occurring in food. Used as a modifier in oxidation dyes including hair dyes & colors. also used as developer in photography; a mordant for dying wool; a reagent for antimony & bismuth; and as a reducer for gold, silver & mercury salts. Used for process engraving & for making colloidal solutions of metals. Used in the manufacture of pharmaceuticals & pesticides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Topical Application)  (C99032)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R: 0, 9.5, 18.75, 37.5, 75, OR 150 MG/KG; 20/SEX/DOSE; M: 0, 38, 75, 150, 300, OR 600 MG/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C99032)  Completed 
    • TR-574 (NIH Number: 13-5916)  (Peer Review Approval 02/08/2012A )
      Toxicology and Carcinogenesis Studies of Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1 Mice (Topical Application Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M: 0, 5, 20, OR 75 MG/KG; 50/SEX/SPECIES/DOSE.

Special Studies

  • Toxicokinetic Study (in-vitro)  (S0825)  Completed 
    • Sprague-Dawley CDF (F344) rat blood
    • Citation: Biological Sample Method Development of Pyrogallol in Rat and Mouse Blood Amended Report. August 27, 2004
    • Rats: Sprague Dawley; Mice: B6C3F1

Genetic Toxicology

  • Micronucleus  (A51963)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Micronucleus  (A76126)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (A22702)  Completed 
    •  Positive 
  • Salmonella  (A98424)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 3 to 7 days Immunotoxicity (Topical Application)  (IMM20103)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 0.5, 1, OR 5%.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.