http://ntp.niehs.nih.gov/go/ts-m960044
Testing Status of Pyrogallol - M960044
CASRN:
87-66-1
Formula:
C6-H6-O3
Synonyms/Common Names
- 1,2,3-Benzenetriol (9CI)
- Pyrogallic acid
- 1,2,3-Trihydroxybenzene
Known Uses
Naturally occurring in food. Used as a modifier in oxidation dyes including hair dyes & colors. also used as developer in photography; a mordant for dying wool; a reagent for antimony & bismuth; and as a reducer for gold, silver & mercury salts. Used for process engraving & for making colloidal solutions of metals. Used in the manufacture of pharmaceuticals & pesticides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.
- 13 weeks (Topical Application)
(C99032)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R: 0, 9.5, 18.75, 37.5, 75, OR 150 MG/KG; 20/SEX/DOSE; M: 0, 38, 75, 150, 300, OR 600 MG/KG; 10/SEX/DOSE.
- 2 years (Topical Application)
(C99032)
Completed
- TR-574 (NIH Number: 13-5916)
(Peer Review Approval 02/08/2012A )
Toxicology and Carcinogenesis Studies of Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1 Mice (Topical Application Studies) - Rats: F344/N; Mice: B6C3F1/N
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats No Evidence
- Male Mice Equivocal Evidence
- Female Mice Some Evidence
- Dose: R&M: 0, 5, 20, OR 75 MG/KG; 50/SEX/SPECIES/DOSE.
- Toxicokinetic Study (in-vitro)
(S0825)
Completed
- Sprague-Dawley CDF (F344) rat blood
- Citation: Biological Sample Method Development of Pyrogallol in Rat and Mouse Blood Amended Report. August 27, 2004
- Rats: Sprague Dawley; Mice: B6C3F1
- Micronucleus
(A51963)
Completed
- Mice: B6C3F1
- Male Equivocal
- Female Negative
- Micronucleus
(A76126)
Completed
- Mice: B6C3F1
- Male Negative
- Salmonella
(A22702)
Completed
- Salmonella
(A98424)
Completed
- 3 to 7 days Immunotoxicity (Topical Application)
(IMM20103)
Completed
- Female Mice: BALB/c
- Dose: 0, 0.5, 1, OR 5%.
