Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.


The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Pyrogallol M960044


CASRN: 87-66-1

Formula: C6-H6-O3

Synonyms/Common Names

  • 1,2,3-Benzenetriol (9CI)
  • Pyrogallic acid
  • 1,2,3-Trihydroxybenzene

Known Uses

Naturally occurring in food. Used as a modifier in oxidation dyes including hair dyes & colors. also used as developer in photography; a mordant for dying wool; a reagent for antimony & bismuth; and as a reducer for gold, silver & mercury salts. Used for process engraving & for making colloidal solutions of metals. Used in the manufacture of pharmaceuticals & pesticides. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Topical Application)  (C99032)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R: 0, 9.5, 18.75, 37.5, 75, OR 150 MG/KG; 20/SEX/DOSE; M: 0, 38, 75, 150, 300, OR 600 MG/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C99032)  Completed 
    • TR-574 (NIH Number: 13-5916)  (Peer Review Approval 02/08/2012A )
      Toxicology and Carcinogenesis Studies of Pyrogallol (CASRN 87-66-1) in F344/N Rats and B6C3F1 Mice (Topical Application Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice Equivocal Evidence 
      • Female Mice Some Evidence 
    • Dose: R&M: 0, 5, 20, OR 75 MG/KG; 50/SEX/SPECIES/DOSE.

Special Studies

  • Toxicokinetic Study (in-vitro)  (S0825)  Completed 
    • Sprague-Dawley CDF (F344) rat blood
    • Citation: Biological Sample Method Development of Pyrogallol in Rat and Mouse Blood Amended Report. August 27, 2004
    • Rats: Sprague Dawley; Mice: B6C3F1

Genetic Toxicology

  • Micronucleus  (A51963)  Completed 
    • Mice: B6C3F1
    • Male Equivocal 
    • Female Negative 
  • Micronucleus  (A76126)  Completed 
    • Mice: B6C3F1
    • Male Negative 
  • Salmonella  (A22702)  Completed 
    •  Positive 
  • Salmonella  (A98424)  Completed 
    •  Positive 

Organ Systems Toxicity

  • 3 to 7 days Immunotoxicity (Topical Application)  (IMM20103)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 0.5, 1, OR 5%.