National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m960054

Testing Status of Toxic equivalency factor evaluation (PCB 153- 2,2'-4,4',5,5'-hexachlorobiphenyl) - M960054

 

CASRN: 35065-27-1

Related: 2,2',4,4',5,5'-HEXACHLOROBIPHENYL (PCB 153)

Formula: C12-H4-Cl6

Synonyms/Common Names

  • 1,1'-Biphenyl, 2,2',4,4',5,5'-hexachloro- (9CI)
  • 2,2'-4,4',5,5'-hexachlorobiphenyl (PCB 153) (Toxic equivalency factor evaluation)
  • PCB 153 (Toxic equivalency factor evaluation)

Known Uses

2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) was produced as a component of some commercial PCB mixtures before 1977 for the electric industry as a dielectric insulating fluid for transformers and capacitors.

Chemical Properties

Toxicity Effects (HSDB)

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C96021)  Report Complete 
    • TR-529 (NIH Number: 06-4465)  (Peer Review Approval 12/09/2004A )
      Toxicology and Carcinogenesis Studies of 2,2',4,4',5,5'-Hexachlorobiphenyl (PCB 153) (CASRN 35065-27-1) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
    • Rats: Harlan Sprague-Dawley
    • Carcinogenesis Results
      • Female Rats Equivocal Evidence 
    • Dose: FEMALE RATS ONLY: PCB-153 -- 0, 10, 100, 300, 1000, OR 3000 UG/KG AND 3000 UG/KG (STOP-EXPOSURE); 50/DOSE.
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