Testing Status of Toxic equivalency factor evaluation (Dioxin mixture) M960056

 

CASRN: TEFDIOXINMIX

Formula: N/A

Synonyms/Common Names

  • Dioxin mixture (Toxic equivalency factor evaluation)
  • Toxic equivalency factor evaluation (Dioxin mixture)

Secondary:

  • 57465-28-8 - 3,3,4,4,5-Pentachlorobiphenyl (PCB 126)
  • 57117-31-4 - 2,3,4,7,8-Pentachlorodibenzofuran
  • 57117-31-4 - Toxic equivalency factor evaluation (PECDF (Pentachlorodibenzofuran))
  • 1746-01-6 - Toxic equivalency factor evaluation (TCDD)
  • 57465-28-8 - TEF transgenics (PCB 126)
  • 57117-31-4 - TEF transgenics (PECDF)
  • 1746-01-6 - TEF transgenics (TCDD)
  • 1746-01-6 - 2,3,7,8-Tetrachlorodibenzo-p-dioxin
  • 57465-28-8 - Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl)
  • 1746-01-6 - Transgenic Model Evaluation (2,3,7,8-Tetrachlorodibenzodioxin)

Known Uses

The main sources of TCDD and PeCDF releases into the environment are from metal smelting, refining, & processing; combustion & incineration sources; chemical manufacturing & processing; biological & photochemical processes; and existing reservior sources that reflect past releases. Used as dielectric insulating fluids in transformers & capacitors and used in hydraulic fluids, plastics, & paints.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C96007B)  Report Complete 
    • TR-526 (NIH Number: 06-4462)  (Peer Review Approval 02/17/2004A )
      Toxicology and Carcinogenesis Studies of a Mixture of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) (CASRN 1746-01-6), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) (CASRN 57117-31-4), and 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) (CASRN 57465-28-8) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
    • Rats: Harlan Sprague-Dawley
    • Carcinogenesis Results
      • Female Rats Clear Evidence 
    • Dose: Female rats only: 0, (TCDD) 3.3, 7.3, 15.2, or 33 ng/kg; (PECDF) 6.6, 14.5, 30.4, or 66 ng/kg; (PCB 126) 33.3, 73.3, 153, or 333 ng/kg; 100/dose.