National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m960057

Testing Status of Magnetic fields + DMBA initiation promotion - M960057

 

CASRN: EMF+DMBA

Related: MAGENTIC FIELDS; DMBA

Formula: N/A

Synonyms/Common Names

  • DMBA + EMF init prom
  • EMF + DMBA init prom
  • Magnetic fields (EMF) + Dimethylbenzanthracene initiation promotion

Secondary:

  • 57-97-6 - 7,12-Dimethylbenzanthracene
  • ELECTROMAG - Magnetic fields (EMF)

Known Uses

Special exposure study to evaluate the potential of 50/60 Hz magnetic fields to promote breast cancer in DMBA treated female Sprague Dawley rats.

Short-Term Toxicity

  • 13 & 26 weeks (Gavage, Whole Body Exposure)  (C89029D)  Completed 
    • Rats: Sprague Dawley
    • Carcinogenesis Results
      •  Equivocal Evidence 
    • Dose: 13-WEEK STUDY (female rats only): 5 mg/rat DMBA @ 4 wkly intervals (total 20 mg DMBA) followed by 50 hz (1 gauss), 60 hz (1 gauss) or 50 hz (5 gauss)/18.5 hr/day. 26-WEEK STUDY (female rats only): 10 mg/rat DMBA followed by 50 hz (1 gauss), 60 hz (1 gauss), or 50 hz (5 gauss)/18.5 hr/day. Controls will receive vehicle (sesame oil) or DMBA with <1 milligauss. 100 per group..
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