National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m960092

Testing Status of Water disinfection byproducts (Sodium chlorate) - M960092

 

CASRN: 7775-09-9

Related: WATER DISINFECTION BYPRODUCTS (DIBROMOACETIC ACID)

Formula: Cl-H-O3.Na

Synonyms/Common Names

  • Chloric acid, sodium salt
  • Sodium chlorate (Water disinfection byproducts)

Known Uses

By-product of chlorine dioxide and hypochlorite in water disinfection. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 3 weeks (Dosed-Water)  (C96010A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 125, 250, 500, 1000, OR 2000 MG/L; 10/SEX/SPECIES/GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C96010A)  Report Complete 
    • TR-517 (NIH Number: 06-4457)  (Peer Review Approval 12/09/2004A )
      Toxicology and Carcinogenesis Studies of Sodium Chlorate (CASRN 7775-09-9) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice No Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R: 0, 125, 1000, OR 2000 MG/L; M: 0, 500, 1000, OR 2000 MG/L; 50/GROUP.

Organ Systems Toxicity

  • 6 to 29 GD Conventional Teratology (Gavage)  (TER97005)  Completed 
    • Citation: Final Study Report Developmental Toxicity Evaluation for Sodium Chlorate (CASRN 7775-09-9) Administered by Gavage to New Zealand White Rabbits on Gestational Days 6 through 29
    • Citation: Final Study Report?Developmental Toxicity Evaluation for Sodium Chlorate (CASRN 7775-09-9) Administered by Gavage to New Zealand White Rabbits on Gestational Days 6 through 29 ?
    • Female Rabbit: New Zealand White
    • Dose: 0, 100, 250, OR 475 MG/KG/DAY.
  • 6 to 29 GD Teratology Pilot Studies (Gavage)  (TRP98001)  Completed 
    • Female Rabbit: New Zealand White
    • Dose: 0, 100, 250, 500, 750 OR 1, 000 MG/KG/DAY.
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