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Testing Status of Water disinfection byproducts (Dibromoacetic acid) M960093

 

CASRN: 631-64-1

Formula: C2-H2-Br2-O2

Synonyms/Common Names

  • Acetic acid, 2,2-dibromo-
  • Dibromoacetic acid (Water disinfection byproducts)

Known Uses

A byproduct of water chlorination

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Dosed-Water)  (C20102)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 1000, OR 2000 MG/L.
  • 2 weeks (Dosed-Water)  (C96017)  Completed 
    • Rats: F344/N; Mice: B6C3F1
  • 13 weeks (Dosed-Water)  (C96017)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 125, 250, 500, 1000, OR 2000 MG/L R: 20/SEX/GROUP M: 10/SEX/GROUP. R&M: 0, 125, 250, 500, 1000, OR 2000 MG/L 10/SEX/GROUP.

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C96017)  Completed 
    • TR-537 (NIH Number: 07-4475)  (Peer Review Approval 09/27/2005A )
      Toxicology and Carcinogenesis Studies of Dibromoacetic Acid (CASRN 631-64-1) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R&M: 0, 50, 500, OR 1000 MG/L; 50/SEX/SPECIES.

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (I96093)  Completed 
    • Female Rats: Harlan Sprague-Dawley
    • Dose: 0, 125, 250, 500, 1000, or 2000 mg/L.
  • 28 days Immunotoxicity (Dosed-Water)  (IMM20501)  Completed 
    • Rats: Sprague Dawley
    • Dose: 0, 125, 250, 500, 1000, OR 2000 MG/L.
  • 28 days Immunotoxicity (Dosed-Water)  (IMM98001)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 125, 250, 500, 1000, OR 2000 MG/L.
  • 28 days Immunotoxicity (Dosed-Water)  (IMM99001)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 125, 250, 500, 1000, OR 2000 MG/LITER.
  • 6 month Neurotoxicology Assessment (Dosed-Water)  (NTA99003)  Completed 
    • Male and Female Rats: F344/N
    • Dose: CONTROL AND 3 DOSES UP TO 2 G/L.