National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m960104

Testing Status of 2-Butyne-1,4-diol - M960104

 

CASRN: 110-65-6

Formula: C4-H6-O2

Synonyms/Common Names

  • Agrisynth B3D
  • 1,4-Butynediol
  • 2-Butyne-1,4-diol
  • 1,4-Dihydroxy-2-butyne

Known Uses

Used in the manufacture of plant protection agents and pesticides, textile additives, corrosion inhibitors, plasticizers, synthetic resins, stabilizers and pharmaceuticals; as a stabilizer for halogenated hydrocarbons; as a mordant retarder; as an additive to nickel-electroplating baths; as an intermediate in the production of butanediol and derivatives. (exec sum)

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0821)  Completed 
    • Citation: 2-Butyne-1,4-Diol: Disposition and Metabolism in Rodents.
    • Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1

Genetic Toxicology

  • Salmonella  (A78093)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.