National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m960119

Testing Status of beta-Myrcene - M960119

 

CASRN: 123-35-3

Formula: C10-H16

Synonyms/Common Names

  • 2-Methyl-6-methylene-2,7-octadiene
  • 7-Methyl-3-methylene-1,6-octadiene
  • 1,6-Octadiene,7-methyl-3-methylene-(8CI 9CI)

Known Uses

Intermediate in the commercial production of terpene alcohols which serve as intermediates for the production of large-volume aroma and flavor chemicals. Used as scenting agents in cosmetics, soaps, and detergents. Beta-myrcene is a peripheral analgesic substance and the active ingredient in lemongrass tea. Identified in over 200 plants and detected in emissions of plywood veneer dryers. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Gavage)  (C99023)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 0.25, 0.5, 1, 2, OR 4 G/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C99023)  Report Complete 
    • TR-557 (NIH Number: 11-5898)  (Peer Review Approval 02/25/2009A )
      Toxicology and Carcinogenesis Studies of beta-Myrcene (CASRN 123-35-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Clear Evidence 
      • Female Rats Equivocal Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Equivocal Evidence 
    • Dose: R&M: 0, 0.25, 0.5, OR 1.0 G/KG; 50/SEX/DOSE.

Genetic Toxicology

  • Micronucleus  (A06528)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A08135)  Completed 
    •  Negative 
  • Salmonella  (A96914)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.