National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m960122

Testing Status of AZT + Clarithromycin combination (AIDS Initiative) - M960122

 

CASRN: AZTCLARITHRO

Related: AIDS INITIATIVE

Formula: N/A

Synonyms/Common Names

  • 3'-Azido-3'-deoxythymidine + clarithromycin combination
  • Clarithromycin + AZT combination

Secondary:

  • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
  • 30516-87-1 - AZT transplacental carcinogenesis study
  • 81103-11-9 - Clarithromycin

Known Uses

Combination of AZT& clarithromycin in experimental treatment of AIDS

Nomination Background

Special Studies

  • Toxicokinetic Study (Gavage)  (S0646)  Completed 
    • Male and Female Mice: B6C3F1

Organ Systems Toxicity

  • 10 to 30 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT96002)  Completed 
    • NIH Number: 04-4418
      Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3'-Azido-3'-deoxythymidine (AZT) and Clarithromycin Combinations (CASRNs 30516-87-1 and 81103-11-9) Administered by Gavage to Swiss (CD-1®) Mice
    • Male and Female Mice: Swiss CD-1
    • Dose: 200 or 400 mg/kg AZT; 500, 1250, or 2500 mg clarithromycin.
  • 10 to 30 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT97001)  Completed 
    • NIH Number: 04-4418
      Citation: NIEHS Technical Report on the Reproductive, Developmental, and General Toxicity Studies of 3'-Azido-3'-deoxythymidine (AZT) and Clarithromycin Combinations (CASRNs 30516-87-1 and 81103-11-9) Administered by Gavage to Swiss (CD-1®) Mice
    • Male and Female Mice: Swiss CD-1
    • Dose: 200 or 400 mg AZT: 250, 500, or 1000 mg clarithromycin.
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