National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m960126

Testing Status of Propargyl alcohol - M960126

 

CASRN: 107-19-7

Formula: C3-H4-O

Synonyms/Common Names

  • Ethynyl carbinol
  • Propynl alcohol
  • 2-Propyn-1-ol (8CI, 9CI)

Known Uses

Used as a reactant/chemical intermediate, pharmaceutical intermediate, agricultural chemical intermediate, soil fumigant, corrosion inhibitor, solvent stabilizer, and polymer modifier. It has also been used to prevent the hydrogen embrittlement of steel.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 2 weeks (Inhalation)  (C97008)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 31.25, 62.5, 125, 250, OR 500 PPM; 5/SEX/SPECIES.
  • 13 weeks (Inhalation)  (C97008)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 4, 8, 16, 32, OR 64 PPM R: 20/SEX M: 10/SEX.

Long-Term Carcinogenicity

  • 2 years (Inhalation)  (C97008)  Report Draft 
    • TR-552 (NIH Number: 08-5893)  (Peer Review Approval 05/17/2007A )
      Toxicology and Carcinogenesis Studies of Propargyl Alcohol (CASRN 107-19-7) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats No Evidence 
      • Male Mice Some Evidence 
      • Female Mice Some Evidence 
    • Dose: R: 0, 16, 32, OR 64 PPM M: 0, 8, 16, OR 32 PPM; 50/SEX/SPECIES.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Inhalation; Intravenous; Topical Application)  (S0815)  Completed 
    • Citation: Disposition and Metabolism of [14C]Propargyl Alcohol (PAL) in Rats and Mice Following Inhalation, Intravenous, and Oral Exposure. March 1998 - February 2000. April 6, 2000.
    • Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N; Male Mice: B6C3F1; Male Rats: F344/N
    • Dose: Rats:inhal:one 6-hr nose-only @ 1 ppm; one 6-hr nose-only @ 100 ppm Mice:inhal:one 6-hr nose-only @ 1 ppm; one 6-hr nose-only @ 100 ppm Rats:IV:single 1 mg/kg Mice:IV:single 1 mg/kg Rats:ORAL:50 mg/kg Mice:ORAL:50 mg/kg Rats:DERMAL:0.5 and 5 mg/kg Rats:DERMAL:0.05, 0.5 and 5 mg/kg.

Genetic Toxicology

  • Micronucleus  (A41608)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Salmonella  (A70312)  Completed 
    •  Positive 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.