National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m970003

Testing Status of Transgenic LEP (Cyclosporin A) - M970003

 

CASRN: 59865-13-3

Related: TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)

Formula: C62-H111-N11-O12

Synonyms/Common Names

  • Cyclosporin A (Transgenic LEP)

Known Uses

Pharmaceutical. Immunosuppressive, drug occurring naturally in fungus. To study carcinogenesis of cyclosporin A in CB6F1-TgHras2 transgenic mice.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 26 weeks (Gavage)  (C97001)  Completed 
    • Mice: CB6F1; Mice: Tg/RASH2/CB6F1
    • Dose: 0, 10, OR 25 MG/KG; 15/GROUP.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.