National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m970013

Testing Status of Saquinavir mesylate (AIDS Initiative) - M970013

 

CASRN: 149845-06-7

Formula: C38-H50-N6-O5.C-H4-O3-S

Synonyms/Common Names

  • Butanediamide, N(1)-3-(3-(((1,1-dimethylethyl)amino)carbonyl)octahydro-2(1H)-isoquinolinyl)-2-hydroxy-1-(phenylmethyl)propyl)-2-((2-quinolinylcarbonyl)amino)-,.....(9CI)
  • Fortovase
  • Invirase

Known Uses

HIV protease inhibitors; antiviral

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (IMM97001)  Completed 
    • Female Mice: B6C3F1
    • Dose: 100, 300, 600, 1000, OR 1200 MG/KG/DAY.
  • 28 days Immunotoxicity (Gavage)  (IMM98009)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 300, 600, OR 1200 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.