Testing Status of Water disinfection byproducts (Bromodichloromethane) M970019

 

CASRN: 75-27-4

Formula: C-H-Br-Cl2

Synonyms/Common Names

  • Bromodichloromethane (Water disinfection byproducts)

Known Uses

Bromodichloromethane is a by-product of the chlorination of drinking water. Solvent. Chemical intermediate. Flame retardant.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 4 weeks (Dosed-Water)  (C20103A)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR & FM: 0, 350, OR 700 MG/L.
  • 4 weeks (Gavage)  (C20103B)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: MR & FM: 0, 50, OR 100 MG/KG.
  • 3 weeks (Dosed-Water)  (C96018)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 43.7, 87.5, 175, 350, OR 700 MG/L; 10/MALE RATS AND 10 FEMALE MICE/GROUP.
  • 13-Week (Dosed-Water)  (C20103A)  Completed 
    • Rats: F344/N; Mice: B6C3F1

Long-Term Carcinogenicity

  • 2 years (Dosed-Water)  (C96018)  Report Complete 
    • TR-532 (NIH Number: 06-4468)  (Peer Review Approval 12/09/2004A )
      Toxicology and Carcinogenesis Studies of Bromodichloromethane (CASRN 75-27-4) in Male F344/N Rats and Female B6C3F1 Mice (Drinking Water Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 175, 350, OR 700 MG/L; 50/GROUP.