National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m970020

Testing Status of Retinoid project 6 (Arotinoid) - M970020

 

CASRN: 125533-88-2

Related: SEE RETINOID PROJECTS 1, 2, 3, 4, 5

Formula: C29-H39-N-O2

Synonyms/Common Names

  • Arotonoid (Retinoid project 6)
  • 4-(2-(p-((E)-2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)propenyl)phenoxy)ethyl)morpholine

Known Uses

Project combining various forms of vitamin A (retinoids) to examine their use in the prevention & intervention of breast cancer.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 18 & 26 weeks (Dosed-Feed)  (C93028I)  Completed 
    • Mice: MMTV/NEU (Tg.Nk)
    • Dose: MICE ONLY: CONTROL W/ AIN 76A DIET & NTP 2000 DIET. AROTONOID ADMINISTERED IN NTP 2000 DIET: 650, 1084 MG/KG. 12/GROUP FOR 18 WEEK; 16/GROUP FOR 26 WEEK.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.