Testing Status of Transgenic model evaluation (WY-14643) M970047

 

CASRN: 50892-23-4

Formula: C14-H14-Cl-N3-O2-S

Synonyms/Common Names

  • (4-Chloro-6-(2,3-dimethylphenyl) amino)-2-pyrimidinyl-1)thio)- acetic acid (9CI)
  • WY-14643 (Transgenic model evaluation)

Known Uses

Developed by the pharmaceutical industry to lower serum cholesterol in humans; not currently used clinically. The objective of this study is to evaluation the transgenic mouse models to identify chemicals for carcinogenic potential.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 26 weeks (Topical Application)  (C97011I)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Dose: MICE ONLY: 0, 2, 10, OR 20 MG/KG; 15/SEX -- 5X/WEEK (WEEKDAYS ONLY AND EXCLUSIVE OF HOLIDAYS).
  • 26 weeks (Dosed-Feed)  (C97011J)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Dose: MICE ONLY: 0, 10, 50, OR 100 PPM; 15/SEX -- 7 DAYS/WEEK FOR 26 CONSECUTIVE WEEKS.