National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m970060

Testing Status of Water disinfection model (Sodium bromate) - M970060

 

CASRN: 7789-38-0

Formula: Br-H-O3.Na

Synonyms/Common Names

  • Bromic acid, sodium salt
  • Sodium bromate (Water disinfection mode)

Known Uses

Analytical reagent, water disinfection by-product. Special initiative using the transgenic mouse model for method development

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C97013B)  Completed 
    • Mice: FVB/N
    • Dose: 0, 16, 32, 64, 128, OR 256 MG/KG.
  • 27 weeks (Dosed-Water)  (C97013A)  Report Complete 
    • GMM-06 (NIH Number: 07-4423)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Sodium Bromate (CASRN 7789-38-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 80, 400, OR 800 MG/L.
  • 43 weeks (Dosed-Water)  (C97013A)  Report Complete 
    • GMM-06 (NIH Number: 07-4423)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Sodium Bromate (CASRN 7789-38-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 80, 400, OR 800 MG/L.
  • 26 weeks (Topical Application)  (C97013B)  Report Complete 
    • GMM-06 (NIH Number: 07-4423)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Sodium Bromate (CASRN 7789-38-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 128, OR 256 MG/KG.
  • 39 weeks (Topical Application)  (C97013B)  Report Complete 
    • GMM-06 (NIH Number: 07-4423)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Sodium Bromate (CASRN 7789-38-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 128, OR 256 MG/KG.
  • 27 weeks (Dosed-Water)  (C97013H)  Report Complete 
    • GMM-06 (NIH Number: 07-4423)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Sodium Bromate (CASRN 7789-38-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 80, 400, OR 800 MG/L.
  • 43 weeks (Dosed-Water)  (C97013H)  Report Complete 
    • GMM-06 (NIH Number: 07-4423)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Sodium Bromate (CASRN 7789-38-0) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Sodium Bromate in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 80, 400, OR 800 MG/L.
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