Testing Status of Water disinfection model (Dichloroacetic acid) M970061

 

CASRN: 79-43-6

Formula: C2-H2-Cl2-O2

Synonyms/Common Names

  • Bichloroacetic acid
  • Dichloracetic acid
  • Dichloroacetic acid (Water disinfection mode)
  • Dichloroethanoic acid

Known Uses

Breakdown product of drinking water disinfectants, astringent, use in treatment of lactic acidosis, keratolytic agent (Merck 1989) special initiative using the transgenic mouse model for method development. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C97013D)  Completed 
    • Mice: FVB/N
    • Dose: 0, 31.25, 62.5, 125, 250, OR 500 MG/KG.
  • 26 weeks (Dosed-Water)  (C97013C)  Completed 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 500, 1000, OR 2000 MG/L.
  • 41 weeks (Dosed-Water)  (C97013C)  Completed 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 500, 1000, OR 2000 MG/L.
  • 26 weeks (Topical Application)  (C97013D)  Report Review 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 31.25, 125, OR 500 MG/KG.
  • 39 weeks (Topical Application)  (C97013D)  Report Review 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 31.25, 125, OR 500 MG/KG.
  • 26 weeks (Dosed-Water)  (C97013I)  Report Review 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 500, 1000, OR 2000 MG/L.
  • 41 weeks (Dosed-Water)  (C97013I)  Report Review 
    • GMM-11 (NIH Number: 07-4428)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Dichloroacetic Acid (CASRN 79-43-6) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal and Drinking Water Studies) and Carcinogenicity Studies of Dichloroacetic Acid in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient Mice (Drinking Water Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 500, 1000, OR 2000 MG/L.