Testing Status of Water disinfection model (Bromodichloromethane) M970062
CASRN: 75-27-4
Formula: C-H-Br-Cl2
Synonyms/Common Names
- Bromodichloromethane (Water disinfection model)
- Water disinfection model (BDCM)
Known Uses
Solvent. Chemical intermediate. Flame retardant. Special initiative using the transgenic mouse model in methods development.
Chemical Properties
Toxicity Effects (HSDB)
Short-Term Toxicity
- 2 weeks (Topical Application)
(C97013F)
Completed
- Mice: FVB/N
- Dose: 0, 16, 32, 64, 128, OR 256 MG/KG.
- 26 weeks (Dosed-Water)
(C97013E)
Report Review
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) - Mice: P53 +/- (C57BL/6)
- Dose: 0, 175, 350, OR 700 MG/L.
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
- 42 weeks (Dosed-Water)
(C97013E)
Report Review
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) - Mice: P53 +/- (C57BL/6)
- Dose: 0, 175, 350, OR 700 MG/L.
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
- 26 weeks (Topical Application)
(C97013F)
Report Review
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) - Mice: Tg.AC (FVB/N) Hemizygous
- Dose: 0, 64, 128, OR 256 MG/KG.
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
- 39 weeks (Topical Application)
(C97013F)
Report Review
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) - Mice: Tg.AC (FVB/N) Hemizygous
- Dose: 0, 64, 128, OR 256 MG/KG.
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
- 26 weeks (Gavage)
(C97013G)
Report Review
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) - Mice: P53 +/- (C57BL/6)
- Dose: 0, 25, 50, OR 100 MG/KG.
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
- 41 weeks (Gavage)
(C97013G)
Report Review
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) - Mice: P53 +/- (C57BL/6)
- Dose: 0, 25, 50, OR 100 MG/KG.
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
- 26 weeks (Dosed-Water)
(C97013J)
Report Review
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) - Mice: Tg.AC (FVB/N) Hemizygous
- Dose: 0, 175, 350, OR 700 MG/L.
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
- 42 weeks (Dosed-Water)
(C97013J)
Report Review
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) - Mice: Tg.AC (FVB/N) Hemizygous
- Dose: 0, 175, 350, OR 700 MG/L.
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
- 26 weeks (Gavage)
(C97013K)
Report Review
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) - Mice: Tg.AC (FVB/N) Hemizygous
- Dose: 0, 25, 50, OR 100 MG/KG.
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
- 41 weeks (Gavage)
(C97013K)
Report Review
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )
Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies) - Mice: Tg.AC (FVB/N) Hemizygous
- Dose: 0, 25, 50, OR 100 MG/KG.
- GMM-05 (NIH Number: 07-4422)
(Peer Review Approval 09/27/2005A )