National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m970062

Testing Status of Water disinfection model (Bromodichloromethane) - M970062

 

CASRN: 75-27-4

Formula: C-H-Br-Cl2

Synonyms/Common Names

  • Bromodichloromethane (Water disinfection model)
  • Water disinfection model (BDCM)

Known Uses

Solvent. Chemical intermediate. Flame retardant. Special initiative using the transgenic mouse model in methods development.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Topical Application)  (C97013F)  Completed 
    • Mice: FVB/N
    • Dose: 0, 16, 32, 64, 128, OR 256 MG/KG.
  • 26 weeks (Dosed-Water)  (C97013E)  Report Review 
    • GMM-05 (NIH Number: 07-4422)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 175, 350, OR 700 MG/L.
  • 42 weeks (Dosed-Water)  (C97013E)  Report Review 
    • GMM-05 (NIH Number: 07-4422)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 175, 350, OR 700 MG/L.
  • 26 weeks (Topical Application)  (C97013F)  Report Review 
    • GMM-05 (NIH Number: 07-4422)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 64, 128, OR 256 MG/KG.
  • 39 weeks (Topical Application)  (C97013F)  Report Review 
    • GMM-05 (NIH Number: 07-4422)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 64, 128, OR 256 MG/KG.
  • 26 weeks (Gavage)  (C97013G)  Report Review 
    • GMM-05 (NIH Number: 07-4422)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 25, 50, OR 100 MG/KG.
  • 41 weeks (Gavage)  (C97013G)  Report Review 
    • GMM-05 (NIH Number: 07-4422)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
    • Mice: P53 +/- (C57BL/6)
    • Dose: 0, 25, 50, OR 100 MG/KG.
  • 26 weeks (Dosed-Water)  (C97013J)  Report Review 
    • GMM-05 (NIH Number: 07-4422)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 175, 350, OR 700 MG/L.
  • 42 weeks (Dosed-Water)  (C97013J)  Report Review 
    • GMM-05 (NIH Number: 07-4422)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 175, 350, OR 700 MG/L.
  • 26 weeks (Gavage)  (C97013K)  Report Review 
    • GMM-05 (NIH Number: 07-4422)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 25, 50, OR 100 MG/KG.
  • 41 weeks (Gavage)  (C97013K)  Report Review 
    • GMM-05 (NIH Number: 07-4422)  (Peer Review Approval 09/27/2005A )
      Toxicology Studies of Bromodichloromethane (CASRN 75-27-4) in Genetically Modified (FVB Tg.AC Hemizygous) Mice (Dermal, Drinking Water, and Gavage Studies) and Carcinogenicity Studies of Bromodichloromethane in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Drinking Water and Gavage Studies)
    • Mice: Tg.AC (FVB/N) Hemizygous
    • Dose: 0, 25, 50, OR 100 MG/KG.
Back to top
Web page last updated on June 16, 2017
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.