National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m970064

Testing Status of Itraconazole - M970064

 

CASRN: 84625-61-6

Formula: C35-H38-Cl2-N8-O4

Synonyms/Common Names

  • 4-(4-(4-(4-((2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
  • Itraconazole (AIDS Initiative)
  • Sporonox

Known Uses

Antifungal. Treatment for fungal infections and is being studied for prevention of histoplasmosis, and for treatment of mild cases of histoplasmosis and blastomycosis.

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (IMM97008)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 10, 20, 40, 80, OR 160 MG/KG/DAY.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.