National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m970076

Testing Status of AZT + Nitazoxanide (AIDS Initiative) - M970076

 

CASRN: AZT+NITAZOX

Related: AIDS INITIATIVE

Secondary:

  • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
  • 30516-87-1 - AZT transplacental carcinogenesis study
  • 55981-09-4 - Nitazoxanide (AIDS initiative)

Known Uses

Combination of AZTand nitazoxanide for treatment of AIDS

Short-Term Toxicity

  • 13 weeks (Gavage)  (C98002)  Completed 
    • Mice: B6C3F1
    • Dose: AZT: 0, 200, OR 400 MG/KG/DAY NITAZOXANIDE 250, 500, OR 1000 MG/KG/DAY.

Organ Systems Toxicity

  • 28 days Repro/Dev Gen Tox (28-Day) (Gavage)  (RDGT97003)  Completed 
    • Male and Female Mice: Swiss CD-1
    • Dose: NITAZOXANIDE: 250, 500, OR 1000 MG/KG/DAY AZT: 200 OR 400 MG/KG/DAY.
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