National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m980023

Testing Status of AZT + Dapsone Combination (Aids Initiative) - M980023

 

CASRN: AZT+DAPSONE

Synonyms/Common Names

  • 3'Azido-3'-deoxythymidine + dapsone
  • Dapsone + AZT

Secondary:

  • 30516-87-1 - 3'-Azido-3'-deoxythymidine (AIDS)
  • 30516-87-1 - AZT transplacental carcinogenesis study
  • 80-08-0 - 4,4'-Sulfonyldianiline (Dapsone)

Known Uses

Combination of drugs being investigated for treatment of HIV

Organ Systems Toxicity

  • 6 to 15 GD Conventional Teratology (Gavage)  (TER98001)  Completed 
    • Citation: Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT; CASRN 30516-87-1) and Dapsone (CASRN 80-08-0) Administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 Through 15 (Laboratory Supplement)
    • Citation: Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT; CASRN 30516-87-1) and Dapsone (CASRN 80-08-0) Administered by Gavage to Swiss Albino (CD-1®) Mice on Gestational Days 6 through 15
    • Female Mice: Swiss CD-1
    • Dose: ALL COMBINATIONS OF AZT (0, 100, 200, OR 400 MG/KG/DAY) PLUS DAPSONE (0, 50, 100, OR 200 MG/KG/DAY).
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