National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m980042

Testing Status of Water disinfection byproducts (Dichloroacetic acid) - M980042

 

CASRN: 79-43-6

Related: DICHLOROACETIC ACID

Formula: C2-H2-Cl2-O2

Synonyms/Common Names

  • 2,2-Dichloroacetic acid
  • Dichloroacetic acid (Water disinfection byproducts)

Known Uses

Breakdown product of drinking water disinfectants, astringent, used in treatment of lactic acidosis, keratolytic agent (Merck 1989). Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Short-Term Toxicity

  • 13 weeks (Dosed-Water)  (C96016)  Completed 
    • Rats: F344/N; Mice: B6C3F1
    • Dose: R&M: 0, 0.067, 0.125, 0.25, 0.5, OR 1.0 G/L; 20/SEX/SPECIES.

Organ Systems Toxicity

  • 28 days Immunotoxicity (Dosed-Water)  (IMM98003)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 125, 250, 500, 1000, OR 2000 MG/LITER.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.