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Testing Status of Endocrine disruptor (Ethinyl estradiol) M980043

 

CASRN: 57-63-6

Formula: C20-H24-O2

Synonyms/Common Names

  • Ethinyl estradiol (Endocrine disruptor)
  • 19-Nor-17-alpha-pregna-1,3,5(10)-trien-20-yne-3,17-diol

Known Uses

Nonsteroidal semi-synthetic estrogen used in the treatment of breast & prostate cancer. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 28 days (Dosed-Feed)  (C20721)  Completed 
    • Rats: Sprague Dawley

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C20721B)  Completed 
    • F1T140
    • TR-548 (NIH Number: 10-5889)  (Peer Review Approval 05/16/2007A )
      Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies)
    • Rats: Harlan Sprague-Dawley
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats Equivocal Evidence 
    • Dose: 0, 2, 10, or 50 ppb.
  • 2 years (Dosed-Feed)  (C20721C)  Histopath in progress 
    • F3T21
    • TR-548 (NIH Number: 10-5889)  (Peer Review Approval 05/16/2007A )
      Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies)
    • Rats: Harlan Sprague-Dawley
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats Equivocal Evidence 
    • Dose: 0, 2, 10, or 50 ppb.
  • 2 years (Dosed-Feed)  (C20721)  Completed 
    • TR-548 (NIH Number: 10-5889)  (Peer Review Approval 05/16/2007A )
      Toxicology and Carcinogenesis Studies of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies)
    • Rats: Sprague Dawley
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
    • Dose: 0, 2, 10, or 50 ppb.

Organ Systems Toxicity

  • Multigenerational Screen (Dosed-Feed)  (MG96006)  Completed 
    • NIH Number: 10-5888
      Citation: Multigenerational Reproductive Toxicology Study of Ethinyl Estradiol (CASRN 57-63-6) in Sprague-Dawley Rats (Feed Studies)
    • Male and Female Rats
    • Reproductive Dose Range Finding (Completed)
      • Days of Treatment: 28 DAYS
      • Dose: 0, 0.1, 1, 5, 25, 100, OR 200 PPM
    • Immunotoxicity (Completed)
      • Days of Treatment: 4 WEEKS
      • Dose: 0, 1, 25, OR 200 PPM
    • Behavioral Toxicity (Completed)
      • Days of Treatment: 10 WEEKS
      • Dose: 0, 1, 5, OR 500 PPM
    • Multigeneration Reproductive Study (F0) (Completed)
      • Days of Treatment: 20 WEEKS
    • Multigeneration Reproductive Study (F1) (Completed)
      • Days of Treatment: 20 WEEKS
    • Multigeneration Reproductive Study (F2) (Completed)
      • Multigeneration Reproductive Study (F3) (Completed)
        • Days of Treatment: 20 WEEKS
      • Multigeneration Reproductive Study (F4) (Completed)
        • Days of Treatment: 20 WEEKS
      • Cancer Study (F1) (Completed)
        • Cancer Study (F3) (Completed)