Testing Status of Pulegone M980045
CASRN: 89-82-7
Formula: C10-H16-O
Synonyms/Common Names
- Cyclohexanone, 5-methyl-2-(1-methylethylidene)-,R-(9CI)
- p-Menth-4(8)-en-3-one, R-(+)- (8CI)
- (+)-R-Pulegone
Known Uses
Major constituent of oil of pennyroyal. Used for flavoring foods and drinks. Pennyroyal oil has been used as a fragrance agent and as an herbal medicine. Associated with tobacco: reported either as a natural component of tobacco, pyrolysis product (in tobacco smoke), or additive for one or more types of tobacco products.
Chemical Properties
Toxicity Effects (HSDB)
Short-Term Toxicity
- 5 days (Gavage)
(C98045)
On Test
- 5-Day Transcriptomic Dose-Response Studies
- Rats: Harlan Sprague-Dawley
- Dose: Male rats: 0, 2.4, 4.7, 9.4, 18.75, 37.5, 75, 150, or 300 mg/kg; N=4.
- 2 weeks (Gavage)
(C99020)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R: 0, 37.5, 75, 150, 300, OR 600 MG/KG; 5/SEX/DOSE M: 0, 18.75, 37.5, 75, 150, OR 300 MG/KG; 5/SEX/DOSE.
- 13 weeks (Gavage)
(C99020)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R&M: 0, 9.375, 18.75, 37.5, 75, OR 150 MG/KG; 10/SEX/DOSE.
Long-Term Carcinogenicity
- 2 years (Gavage)
(C99020)
Completed
- TR-563 (NIH Number: 10-5905)
(Peer Review Approval 11/19/2009A )
Toxicology and Carcinogenesis Studies of Pulegone (CASRN 89-82-7) in F344/N Rats and B6C3F1 Mice (Gavage Studies) - Rats: F344/N; Mice: B6C3F1/N
- Carcinogenesis Results
- Male Rats No Evidence
- Female Rats Some Evidence
- Male Mice Clear Evidence
- Female Mice Clear Evidence
- Dose: MALE RATS: 0, 18.75, 37.5, OR 75 MG/KG; FEMALE RATS AND MALE & FEMALE MICE: 0, 37.5, 75, OR 150 MG/KG.
- TR-563 (NIH Number: 10-5905)
(Peer Review Approval 11/19/2009A )
Special Studies
- Absorption Disposition Metabolism Elimination (Gavage; Intravenous)
(S0668)
Completed
- Citation: Chen LJ, Lebetkin EH, Burka LT. Metabolism of (R)-(+)-pulegone in F344 rats. Drug Metab Dispos. 2001 Dec;29(12):1567-77.Pubmed Abstract
- Male and Female Rats: F344/N; Male and Female Mice: B6C3F1; Rats: F344/N
- Dose: 0.8, 8, 80, 160 mg/kg.
Genetic Toxicology
- Micronucleus
(A36729)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(A17590)
Completed
- Negative
- Salmonella
(A65321)
Completed
- Negative
- Salmonella
(G98045)
Completed
- Positive
Toxicogenomics
- 5 days Transcriptome Sequencing (Gavage)
(T98045)
Assigned
- 5-Day Transcriptomic Dose-Response Studies
- Rats: Harlan Sprague-Dawley