National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m980047

Testing Status of Goldenseal extract - M980047

 

CASRN: 84603-60-1

Related: BERBERINE (2086-83-1) & HYDRASTINE (118-08-1)

Formula: N/A

Synonyms/Common Names

  • EGS
  • Extract of goldenseal
  • Goldenseal, Hydrastis canadensis extract
  • Hydrastis canadensis extract

Known Uses

Natural herbal remedy from root extract, used by native Americans to treat wounds, ulcers, digestive disorders, and skin and eye ailments. Also used to treat a variety of digestive and hemorrhagic disorders. Thought to possess slight antiseptic, astringent, and hemostatic qualities when applied topically. Commonly consumed as an herbal tea. (NTP exec. Summary - 1997)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C98047)  On Test 
    • 5 day
    • Rats: F344/NCrl (SAS FISCH)
    • Dose: Golden Seal Extract; 0, 94, 188, 375, 750, or 1500 mg/kg; 6 males/group.

Genetic Toxicology

  • Micronucleus (Gavage)  (G98047)  On Test 
    • Rats: F344/N Charles River

Toxicogenomics

  • Microarray Analysis (Gavage) Selected (T98047)  
    • Rats: F344/NTac
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.