National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m980049

Testing Status of Etoposide - M980049

 

CASRN: 33419-42-0

Formula: C29-H32-O13

Synonyms/Common Names

  • 4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside
  • Epipodophyllotoxin, 4'-demethyl-,4,6-O-ethylidene-beta-D-glucopyranoside (8CI)

Known Uses

Antineoplastic; semisynthetic derivative of podophyllotoxic that inhibits the entry of cells into mitosis; is effective against some neoplasms Antineoplastic Agents, Phytogenic; Nucleic Acid Synthesis Inhibitors

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • single Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98037)  Completed 
    • Female Mice: SEC/E X C57B1/E
    • Dose: 40 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.