National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m980052

Testing Status of Camptothecin - M980052

 

CASRN: 7689-03-4

Formula: C20-H16-N2-O4

Synonyms/Common Names

  • 1H-Pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-

Known Uses

Antineoplastic agent; phytogenic. Alkaloid exhibiting antileukemic and antitumor activities isolated from the stem wood of the Chinese tree camtotheca acuminata (Merck, 11th ed)

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • single exposure Total Reproductive Capacity (Intraperitoneal Injection)  (TRC98033)  Completed 
    • Female Mice: (SEC/E X C57BL/E)F1
    • Dose: 10 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.