National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m980065

Testing Status of bis(2-Chloroethoxy)methane - M980065

 

CASRN: 111-91-1

Formula: C5-H10-Cl2-O2

Synonyms/Common Names

  • CEM
  • Dichloroethyl formal
  • Ethane, 1,1'-(methylenebis(oxy))bis(2-chloro-
  • Formaldehyde bis(2-chloroethyl) acetal

Known Uses

Used as a starting compound to produce polysulfide elastomers. Also used as a solvent

Chemical Properties

Toxicity Effects (HSDB)

Nomination Background

Planned Carcinogenicity/Toxicity

  • Single dose (Gavage) Selected (C98065)  
    • Pilot cardiotoxicity study in the DO mouse model
    • Mice: Diversity Outbred (Jackson)

Short-Term Toxicity

  • 3 days (Gavage)  (C99028B)  Completed 
    • Mice: B6C3F1
    • Dose: MM: 0, 50, 100, 150, 200, or 300 mg/kg.
  • 10 days (Gavage)  (C99028C)  Completed 
    • Mice: B6C3F1/J (Jackson); Mice: C3H/HeJ; Mice: C57BL/6J (Jackson)
    • Dose: Study A (beginning on 5/25): 0, 50, 100, 150, 200, or 300 mg/kg; Study B (beginning on 4/14 C3H/HeJ,5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 150, 200, or 300 mg/kg.
  • 3 days (Gavage)  (C99028C)  Completed 
    • Mice: B6C3F1/J (Jackson); Mice: C3H/HeJ; Mice: C57BL/6J (Jackson)
    • Dose: Study A (beginning on 5/25): 0, 50, 100, 150, 200, or 300 mg/kg; Study B (beginning on 4/14 C3H/HeJ, 5/19 C57BL/6J, 6/30 B6C3F1/J,: 0, 150, 200, or 300 mg/kg. Study A (beginning on 5/25): 0, 50, 100, 150, 200, or 300 mg/kg; Study B (beginning on 4/14 C3H/HeJ,5/19 C57BL/6J, 6/30 B6C3F1/J: 0, 150, 200, or 300 mg/kg.
  • 2 weeks (Topical Application)  (C99028)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 12.5, 25, 50, 100, OR 200 MG/KG; 5/SEX/DOSE.
  • 13 weeks (Topical Application)  (C99028)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 50, 100, 200, 400, OR 600 MG/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Topical Application)  (C99028)  Completed 
    • TR-536 (NIH Number: 10-5904)  (Peer Review Approval 11/19/2009A )
      Toxicology and Carcinogenesis Studies of bis(2-Chloroethoxy)methane (CASRN 111-91-1) in F344/N Rats and B6C3F1 Mice (Dermal Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R: 0, 75, 150, OR 300 MG/KG; MM: 0, 150, 300 OR 600 MG/KG; FM: 0, 100, 200, OR 400 MG/KG.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; Topical Application)  (S0816)  Completed 
    • Citation: Bis (2-chloroethoxy) Methane: Comparative Metabolism and Excretion in Rats and Mice. 05/06/1999 - 02/28/2002. February 28, 2002.
    • Male Rats: F344/N; Male and Female Mice: B6C3F1; Male Rats: F344/N; Male and Female Mice: B6C3F1; Male Rats: F344/N; Male and Female Mice: B6C3F1

Genetic Toxicology

  • Micronucleus  (A22073)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Micronucleus  (A53820)  Completed 
    • Rats: Fischer 344
    • Male Negative 
  • Salmonella  (A20931)  Completed 
    •  Equivocal 
  • Salmonella  (A92025)  Completed 
    •  Positive 

Toxicogenomics

  • Microarray Analysis (Gavage) Selected (T98065)  
    • Mice: Diversity Outbred (Jackson)
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.