National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m980066

Testing Status of Transgenic LECM (Tetradecanoyl phorbol acetate (TPA)) - M980066

 

CASRN: 16561-29-8

Related: TETRACANOYL PHORBOL ACETATE

Formula: C36-H56-O8

Synonyms/Common Names

  • Tetradecanoyl phorbol acetate (TPA) (Transgenic LECM)
  • TPA (Transgenic LECM)

Known Uses

In cancer research to study mechanisms of tumor promotion. To screen for potential inhibiting agents. Positive control for tumor promoting agents, found in croton oil (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 26 weeks (Topical Application)  (C98005)  Completed 
    • Mice: Tg.AC (FVB/N) Homozygous
    • Dose: 2.5 UG IN 200 UL; 2X/WK.
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