Testing Status of Goldenseal root powder M980070
CASRN: GOLDENSEALRT
Related: BERBERINE, GOLDEN SEAL, HYDRASTINE
Synonyms/Common Names
- Powdered root of goldenseal
Known Uses
A natural herbal remedy
Short-Term Toxicity
- 2 weeks (Dosed-Feed)
(C99007)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R&M: 0, 1560, 3121, 6250, 12500, 25000 OR 50000 PPM; 5/SEX/SPECIES.
- 13 weeks (Dosed-Feed)
(C99007B)
Completed
- Rats: F344/N; Mice: B6C3F1/N
- Dose: R&M: 0, 3125, 6250, 12500, 25000, OR 50000 PPM; 10/SEX/SPECIES.
Long-Term Carcinogenicity
- 2 years (Dosed-Feed)
(C99007B)
Completed
- TR-562 (NIH Number: 10-5903)
(Peer Review Approval 02/25/2009A )
Toxicology and Carcinogenesis Studies of Goldenseal Root Powder (HYDRASTIS CANADENSIS) in F344/N Rats and B6C3F1 Mice (Feed studies) - Rats: F344/N; Mice: B6C3F1/N
- Carcinogenesis Results
- Male Rats Clear Evidence
- Female Rats Clear Evidence
- Male Mice Some Evidence
- Female Mice No Evidence
- Dose: R&M: 0, 3000, 9000, OR 25, 000 PPM.
- TR-562 (NIH Number: 10-5903)
(Peer Review Approval 02/25/2009A )
Special Studies
- Absorption Disposition Metabolism Elimination (in-vitro)
(S0856)
Completed
- Citation: Etheridge AS, Black SR, Patel PR, So J, Mathews JM. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med. 2007 Jul;73(8):731-41. Epub 2007 Jul 5. PubMed PMID: 17611934.Pubmed Abstract
- Citation: Final Study Report. Goldensealrt: Interaction of Extracts with Cytochrome P450 Enzymes and P-glycoprotein. Studies of Chemical Disposition in Mammals. 10/14/2002 - 02/28/2006.
- Human (Cell Lines)
- Dose: 0, 1, 10, 100 uM..
Genetic Toxicology
- Micronucleus
(A21831)
Completed
- Mice: B6C3F1
- Male Negative
- Female Negative
- Salmonella
(A83314)
Completed
- Negative
Organ Systems Toxicity
- 6 to 20 GD Conventional Teratology (Dosed-Feed)
(TER98007)
Completed
- Citation: FINAL STUDY REPORT DEVELOPMENTAL TOXICITY EVALUTATION FOR GOLDENSEAL ROOT POWDER (HYDRASTIS CANADENSIS) ADMINISTERED IN THE FEED TO SPRAGUE-DAWLWY (CD(r)) RATS ON GESTATIONAL DAYS 6 TO 20
- Citation: Final Study Report Developmental Toxicity Evaluation for Goldenseal Root Powder (Hydrastis Canadensis) Administered in the Feed to Sprague-Dawley (CD®) Rats on Gestational Days 6 to 20
- Female Rats: Sprague Dawley
- Dose: 0, 3125, 6250, 12, 500 OR 18, 400 PPM.
- 6 to 17 GD Conventional Teratology (Dosed-Feed)
(TER99004)
Completed
- Citation: Final Study Report Developmental Toxicity Evaluation for Goldenseal (Hydrastis canadensis) root powder Administered in the Feed to Swiss (CD-1®) Mice on Gestational Days 6-17
- Citation: Final Study Report?Developmental Toxicity Evaluation for Goldenseal (Hydrastis canadensis) root powder Administered in the Feed to Swiss (CD-1®) Mice on Gestational Days 6-17
- Female Mice: Swiss CD-1
- Dose: 0, 3125, 12, 500, OR 50, 000 PPM.
- 6 to 20 GD Teratology Pilot Studies (Dosed-Feed)
(TRP98007)
Completed
- Rats: Sprague Dawley
- Dose: 0, 3125, 6250, 12, 500, 25, 000, OR 50, 000 PPM.
- 6 to 17 GD Teratology Pilot Studies (Dosed-Feed)
(TRP99007)
Completed
- Female Mice: Swiss CD-1
- Dose: 0, 3125, 6250, 12, 500, 25, 000 OR 50, 000 PPM.