National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m980079

Testing Status of Lovastatin - M980079

 

CASRN: 75330-75-5

Formula: C24-H36-O5

Synonyms/Common Names

  • Altocor
  • Cholestra
  • Mavacor
  • Mevinacor
  • [1 S -[1a(R*),3a, 7b, 8b (2 S*, 4 S*), 8ab]]-1,2,3, 7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2 H-pyran-2-yl)ethyl]-1-naphthalenyl2-methylbutanoate

Known Uses

Antilipemic; a cholesterol-lowering agent isolated from a strain of Aspergillis terreus.

Chemical Properties

Toxicity Effects (HSDB)

Organ Systems Toxicity

  • 28 days Immunotoxicity (Gavage)  (IMM20503)  Completed 
    • Female Mice: B6C3F1
    • Dose: 0, 0.5, 2, 5, 20, or 50 mg/kg/day.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.