National Toxicology Program

Testing Status of 2,2',4,4',5-Pentabromodiphenyl Ether - M980089

CASRN: 60348-60-9

Formula: C12-H5-Br5-O

Synonyms/Common Names

• BDE 99
• Benzene, 1,2,4-tribromo-5-(2,4-dibromophenoxy)-(9CI)
• PBDE 99
• Tardex 50

Known Uses

Flame-retarding additives in polymers used in computers, cars, airplanes & in textiles in public buildings.

Chemical Properties

Toxicity Effects (HSDB)

Planned Carcinogenicity/Toxicity

• GD 6 to PND 21 (gestation dams) (Gavage) Selected (C98089)  
  • BDE Toxicogenomics Study
  • Rats: Wistar Han
• PND 1 to PND 4 (lactation dams) (Gavage) Selected (C98089)  
  • BDE Toxicogenomics Study
  • Rats: Wistar Han
• PND 4 to PND 21 (female pups) (Gavage) Selected (C98089)  
  • BDE Toxicogenomics Study
  • Rats: Wistar Han
• PND 4 to PND 21 (male pups) (Gavage) Selected (C98089)  
  • BDE Toxicogenomics Study
  • Rats: Wistar Han
• 13 weeks (Gavage) Selected (C98089)  
  • BDE Toxicogenomics Study
  • Rats: Wistar Han; Mice: B6C3F1

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0920)  Completed 
  • Citation: Chen LJ, Lebetkin EH, Sanders JM, Burka LT. Metabolism and disposition of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice. Xenobiotica. 2006 Jun;36(6):515-34.Pubmed Abstract
  • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
  • Dose: From 0.1 to 1000 umol/kg.
• C. elegans  (W98089)  Completed 
  • C. elegans: N2
  • Dose: Growth:0, 0.1, 0.16, 0.25, 0.40, 0.63, 1, 1.6, 2.5, 4, 6.3, 10uMRepro:0, 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, 6.3, 13, 25, 50, 100uM Feeding:0, 0.5, 0.79, 1.3, 2.0, 3.2, 5.0, 7.9, 13, 20, 32, 50uM.

Genetic Toxicology

• Salmonella  (A93319)  Completed 
  •  Negative