Testing Status of 2,2',4,4',5-Pentabromodiphenyl Ether M980089

CASRN: 60348-60-9

Formula: C12-H5-Br5-O

Synonyms/Common Names

• BDE 99
• Benzene, 1,2,4-tribromo-5-(2,4-dibromophenoxy)-(9CI)
• PBDE 99
• Tardex 50

Known Uses

Flame-retarding additives in polymers used in computers, cars, airplanes & in textiles in public buildings.

Chemical Properties

Toxicity Effects (HSDB)

Special Studies

• Absorption Disposition Metabolism Elimination (Gavage)  (S0920)  Completed 
  • Citation: Chen LJ, Lebetkin EH, Sanders JM, Burka LT. Metabolism and disposition of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) following a single or repeated administration to rats or mice. Xenobiotica. 2006 Jun;36(6):515-34.Pubmed Abstract
  • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
  • Dose: From 0.1 to 1000 umol/kg.
• C. elegans  (W98089)  Completed 
  • Citation: Behl M, Rice JR, Smith MV, Co CA, Bridge M, Hsieh JH, Freedman JH, Boyd WA. Comparative toxicity of organophosphate flame retardants and polybrominated diphenyl ethers to c. Elegans. Toxicol Sci. 2016 Aug;154(2):241-252Pubmed Abstract
  • C. elegans: N2
  • Dose: Growth:0, 0.1, 0.16, 0.25, 0.40, 0.63, 1, 1.6, 2.5, 4, 6.3, 10uMRepro:0, 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, 6.3, 13, 25, 50, 100uM Feeding:0, 0.5, 0.79, 1.3, 2.0, 3.2, 5.0, 7.9, 13, 20, 32, 50uM.

Genetic Toxicology

• Salmonella  (A93319)  Completed 
  •  Negative