National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m980090

Testing Status of 2,2',4,4'-Tetrabromodiphenyl Ether - M980090

 

CASRN: 5436-43-1

Formula: C12-H6-Br4-O

Synonyms/Common Names

  • BDE-47
  • Benzene,1,1'-oxybis(2,4-dibromo)-(9CI)
  • DE-47
  • Flame Retardant 2
  • PBDE 47

Known Uses

Flame-retarding additives in polymers used in computers, cars, airplanes & in textiles in public buildings.

Chemical Properties

Toxicity Effects (HSDB)

Planned Carcinogenicity/Toxicity

  • GD 6 to PND 21 (gestation dams) (Gavage) Selected (C98090)  
    • BDE Toxicogenomics Study
    • Rats: Wistar Han
  • PND 1 to PND 4 (lactation dams) (Gavage) Selected (C98090)  
    • BDE Toxicogenomics Study
    • Rats: Wistar Han
  • PND 4 to PND 21 (female pups) (Gavage) Selected (C98090)  
    • BDE Toxicogenomics Study
    • Rats: Wistar Han
  • PND 4 to PND 21 (male pups) (Gavage) Selected (C98090)  
    • BDE Toxicogenomics Study
    • Rats: Wistar Han
  • 13 weeks (Gavage) Selected (C98090)  
    • BDE Toxicogenomics Study
    • Rats: Wistar Han; Mice: B6C3F1

Short-Term Toxicity

  • PND 12 to 21 (Gavage)  (C20208)  Completed 
    • Mice: BALB/cByJ; Mice: CB6F1-Tg(HRAS)2Jic [(BALB/cByJTac x C57BL/6JTac)-Tg(HRAS)2Jic F1
    • Dose: FM: 0, 25, 50, 100, OR 200 mg/kg.
  • Special study (Gavage)  (C20208)  Completed 
    • Mice: CB6F1-Tg(HRAS)2Jic [(BALB/cByJTac x C57BL/6JTac)-Tg(HRAS)2Jic F1
  • 5 days (Gavage)  (C98090C)  On Test 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.
  • GD 6 to PND 21 (Gavage)  (C98090B)  Completed 
    • Tier One BDE TGMX Study
    • Rats: Wistar Han
  • GD 6 to GD 20 (Gavage)  (C98090B)  Completed 
    • Tier One BDE TGMX Study
    • Rats: Wistar Han
  • GD 6 to PND 21 (Gavage)  (C98090B)  Completed 
    • Tier One BDE TGMX Study
    • Rats: Wistar Han
    • Dose: 0, 0.1, 15, 50 mg/kg/10 dams/group.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0921)  Completed 
    • Citation: Sanders JM, Chen LJ, Lebetkin EH, Burka LT. Metabolism and disposition of 2,2',4,4'- tetrabromodiphenyl ether following administration of single or multiple doses to rats and mice. Xenobiotica. 2006 Jan;36(1):103-17.Pubmed Abstract
    • Male and Female Rats: F344/N; Male and Female Mice: B6C3F1
    • Dose: From 0.1 to 1000 umol/kg.
  • C. elegans  (W98090)  Completed 
    • C. elegans: N2
    • Dose: Growth:0, 0.1, 0.16, 0.25, 0.40, 0.63, 1, 1.6, 2.5, 4, 6.3, 10uMRepro:0, 0.1, 0.2, 0.4, 0.8, 1.6, 3.2, 6.3, 13, 25, 50, 100uM Feeding:0, 1, 1.6, 2.5, 4.0, 6.3, 10, 16, 25, 40, 63, 100uM.

Genetic Toxicology

  • Salmonella  (A90466)  Completed 
    •  Negative 

Toxicogenomics

  • 5 days Microarray Analysis (Gavage)  (T98090B)  Assigned 
    • Rats: Hsd:Sprague Dawley SD
    • Dose: 0, 0.1, 1, 10, 100, or 1000 umol/kg; 6 males/group.
  • Microarray Analysis (Gavage) Selected (T98090)  
    • Tier One BDE TGMX Study
    • Rats: Wistar Han
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.