National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m990005

Testing Status of Transgenic model evaluation (Bromodichloromethane) - M990005

 

CASRN: 75-27-4

Related: WATER DISINFECTION BYPRODUCTS AND WATER DISINFECTION MODEL STUDIES

Formula: C-H-Br-Cl2

Synonyms/Common Names

  • BromodichloromethaneE (Transgenic model evaluation)
  • Methane, bromodichloro-

Known Uses

Special study to evaluate the use of special transgenic mouse model in testing of bromodichloromethane.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 26 weeks (Dosed-Water)  (C99001B)  Completed 
    • Mice: C57BL/6-APC+/APC-1638N (Tg:APC)
    • Dose: 0 OR 700 PPM -- DECREASED TO 350 PPM DUE TO REDUCED WATER CONSUMPTION; 0: 13 MALES & 8 FEMALES PER GROUP; 700(350) 13 MALES & 9 FEMALES PER GROUP.
  • 26 weeks (Gavage)  (C99001)  Completed 
    • Mice: C57BL/6-APC+/APC-1638N (Tg:APC)
    • Dose: 0, 5, OR 10 MG/ML; FEMALES: 12/DOSE MALES: 14/DOSE.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.