National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m990020

Testing Status of Styrene-acrylonitrile trimer - M990020

 

CASRN: SANTRIMER2

Known Uses

SAN Trimer is a by-product of the production of acrylonitrile styrene plastics and is created in specific manufacturing processes for polymers of acrylonitrile and styrene.

Short-Term Toxicity

  • 7 weeks (Dosed-Feed)  (C99013)  Completed 
    • Rats: F344/N
    • Dose: R: 0, 250, 500, 1000, 2000, OR 4000 PM; 10/SEX/DOSE.
  • 18 weeks (Dosed-Feed)  (C99013)  Completed 
    • Rats: F344/N
    • Dose: R: 0, 100, 200, 400, 800, OR 1600 PPM; 20/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Dosed-Feed)  (C99013)  Report Complete 
    • TR-573 (NIH Number: 11-5915)  (Peer Review Approval 01/26/2011A )
      Toxicology and Carcinogenesis Study of Styrene-Acrylonitrile Trimer (CASRN SANTRIMER2) in F344/N Rats (Perinatal and Postnatal Feed Studies)
    • Rats: F344/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
    • Dose: R: 0, 400, 800, OR 1600 PPM; 50/SEX/DOSE.

Genetic Toxicology

  • Comet Assay Selected (G99020)  
    • Rats: F344/NTac
  • Comet Assay (Gavage)  (G99020C)  Completed 
    • Rats: Fischer 344
  • Micronucleus  (G99020B)  Completed 
    • Rats: F344/NTac
    • Male Positive 
    • Female Positive 
  • Salmonella  (A04901)  Completed 
    •  Negative 
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.