National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m990028

Testing Status of Prevention 2 (Silymarin + melatonin) - M990028

 

CASRN: SILYMARN+MEL

Synonyms/Common Names

  • Melatonin + silymarin (Prevention 2)
  • Silymarin + melatonin (Prevention 2)

Secondary:

  • 73-31-4 - Melatonin
  • 73-31-4 - Prevention 1 (Melatonin)
  • 73-31-4 - Prevention 2 (Melatonin)
  • 65666-07-1 - Prevention 2 (Silymarin)
  • 73-31-4 - Prevention 3 (Melatonin)
  • 73-31-4 - Prevention 6 (Melatonin)
  • 73-31-4 - Prevention 4 (Melatonin)
  • 73-31-4 - Prevention 5 (Melatonin)
  • 65666-07-1 - Silymarin

Known Uses

Drug/therapeutic agent. Prevention 2 is a special study to examine dietary intervention to prevent/delay breast cancer.

Short-Term Toxicity

  • 26 weeks (Dosed-Feed)  (C99014C)  Completed 
    • Mice: MMTV/NEU (Tg.Nk)
    • Dose: MEL 0.028% + SIL 0.05%; MEL 0.112% + SIL 0.20%.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.