Testing Status of Ginkgo biloba extract M990050

 

CASRN: 90045-36-6

Synonyms/Common Names

  • GBE
  • Maidenhair extract

Known Uses

Herbal supplement

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 5 days (Gavage)  (C99050)  On Test 
    • GBE 3 (D072/030/A14)
    • Rats: F344/NCrl (SAS FISCH)
    • Dose: Ginkgo Biloba Extract (Lot 1-5) 0, 3, 30, 100, 300, or 1000 mg/kg; 6 males/group.
  • 13 weeks (Gavage)  (C99031)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R: 0, 62.5, 125, 250, 500 OR 1000 MG/KG; 20/SEX/DOSE; M: 0, 125, 250, 500, 1000 OR 2000 MG/KG; 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C99031)  Completed 
    • TR-578 (NIH Number: 13-5920)  (Peer Review Approval 02/08/2012A )
      Toxicology and Carcinogenesis Studies of Ginkgo Biloba Extract (CASRN 90045-36-6) in F344/N Rats and B6C3F1/N Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Some Evidence 
      • Female Rats Some Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 100, 300, OR 1000 MG/KG; M: 0, 200, 600, OR 2000 MG/KG; 50/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0859)  Completed 
    • Citation: Etheridge AS, Black SR, Patel PR, So J, Mathews JM. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med. 2007 Jul;73(8):731-41. Epub 2007 Jul 5. PubMed PMID: 17611934.Pubmed Abstract
    • Citation: Final Study Report Ginkgo Extract: Interaction with Cytochrome P450 Enzymes and P-glycoprotein.
    • Human (Cell Lines)
    • Dose: 0, 1, 10 µM..
  • Toxicokinetic Study (Gavage)  (K99050)  On Test 
    • GBE 1 (020703)
    • Male Rats: F344/N Charles River
    • Dose: 0, 30, 100, 300 mg/kg/day.

Genetic Toxicology

  • Micronucleus  (A97646)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Micronucleus (Gavage)  (G99050B)  On Test 
    • Ginkgo Biloba Extract Lot # 2
    • Rats: F344/N Charles River
  • Micronucleus (Gavage)  (G99050C)  On Test 
    • Ginkgo Biloba Extract Lot # 3
    • Rats: F344/N Charles River
  • Micronucleus (Gavage)  (G99050D)  On Test 
    • Ginkgo Biloba Extract Lot # 4
    • Rats: F344/N Charles River
  • Micronucleus (Gavage)  (G99050E)  On Test 
    • Ginkgo Biloba Extract Lot # 5
    • Rats: F344/N Charles River
  • Micronucleus (Gavage)  (G99050)  On Test 
    • Ginkgo Biloba Extract Lot # 1
    • Rats: F344/N Charles River
  • Salmonella  (A33386)  Completed 
    •  Positive 

Toxicogenomics

  • 5 days Microarray Analysis (Gavage)  (T99050)  On Test 
    • GBE 3 (D072/030/A14)
    • Rats: F344/N Charles River
    • Dose: Ginkgo Biloba Extract (Lot 1-5) 0, 3, 30, 100, or 1000 mg/kg; 6 males/group; Green Tea Extract; 0, 3, 30, 100, or 1000 mg/kg; 6 males/group; Golden Seal Extract; 0, 94, 188, 375, 750, or 1500 mg/kg; 6 males/group.