Skip to Main Navigation
Skip to Page Content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Testing Status of Ginseng M990057

 

CASRN: 50647-08-0

Formula: N/A

Synonyms/Common Names

  • Panax
  • Prosapogenin

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C20005)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 0.125, 0.25, 0.5, 1.0, OR 2.0 G/KG; 5/SEX/SPECIES/DOSE.
  • 5 days (Gavage)  (C99057)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 39.1, 78.125, 156.25, 317.5, 625, 1250, 2500, or 5000 mg/kg; N=4.
  • 13 weeks (Gavage)  (C20005)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 1, 2, 3, 4, OR 5 G/KG; R: 20/SEX/DOSE; M: 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20005)  Completed 
    • TR-567 (NIH Number: 10-5909)  (Peer Review Approval 11/19/2009A )
      Toxicology and Carcinogenesis Studies of Ginseng (CASRN 50647-08-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 1.25, 2.5, OR 5.0 G/KG; 50/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0940)  Completed 
    • Citation: Absorption, Distribution, Metabolism, Excretion (ADME) Chemical Disposition in Mammals Final Study Report P450 Inhibition Assays (Study of Ginseng)
    • Citation: Etheridge AS, Black SR, Patel PR, So J, Mathews JM. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med. 2007 Jul;73(8):731-41. Epub 2007 Jul 5. PubMed PMID: 17611934.Pubmed Abstract
    • Human (Cell Lines)
    • Dose: 0, 1, 10 UM.

Genetic Toxicology

  • Micronucleus  (A82446)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A04849)  Completed 
    •  Negative 
  • Salmonella  (A16457)  Completed 
    •  Negative 

Toxicogenomics

  • 5-day Transcriptome Sequencing (Gavage)  (T99057)  On Test 
    • Rats: Harlan Sprague-Dawley