National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m990057

Testing Status of Ginseng - M990057

 

CASRN: 50647-08-0

Formula: N/A

Synonyms/Common Names

  • Panax
  • Prosapogenin

Known Uses

Used as herbal remedy, dietary supplement, food additive; also used in cosmetics

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C20005)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 0.125, 0.25, 0.5, 1.0, OR 2.0 G/KG; 5/SEX/SPECIES/DOSE.
  • 5 days (Gavage)  (C99057)  On Test 
    • 5-Day Transcriptomic Dose-Response Studies
    • Rats: Harlan Sprague-Dawley
    • Dose: Male rats: 0, 39.1, 78.125, 156.25, 317.5, 625, 1250, 2500, or 5000 mg/kg; N=4.
  • 13 weeks (Gavage)  (C20005)  Completed 
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 1, 2, 3, 4, OR 5 G/KG; R: 20/SEX/DOSE; M: 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20005)  Completed 
    • TR-567 (NIH Number: 10-5909)  (Peer Review Approval 11/19/2009A )
      Toxicology and Carcinogenesis Studies of Ginseng (CASRN 50647-08-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats No Evidence 
      • Female Rats No Evidence 
      • Male Mice No Evidence 
      • Female Mice No Evidence 
    • Dose: R&M: 0, 1.25, 2.5, OR 5.0 G/KG; 50/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (in-vitro)  (S0940)  Completed 
    • Citation: Absorption, Distribution, Metabolism, Excretion (ADME) Chemical Disposition in Mammals Final Study Report P450 Inhibition Assays (Study of Ginseng)
    • Citation: Etheridge AS, Black SR, Patel PR, So J, Mathews JM. An in vitro evaluation of cytochrome P450 inhibition and P-glycoprotein interaction with goldenseal, Ginkgo biloba, grape seed, milk thistle, and ginseng extracts and their constituents. Planta Med. 2007 Jul;73(8):731-41. Epub 2007 Jul 5. PubMed PMID: 17611934.Pubmed Abstract
    • Human (Cell Lines)
    • Dose: 0, 1, 10 UM.

Genetic Toxicology

  • Micronucleus  (A82446)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A04849)  Completed 
    •  Negative 
  • Salmonella  (A16457)  Completed 
    •  Negative 

Toxicogenomics

  • 5-day Transcriptome Sequencing (Gavage) Selected (T99057)  
    • Rats: Harlan Sprague-Dawley
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.