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Testing Status of Kava kava extract M990058

 

CASRN: 9000-38-8

Formula: N/A

Synonyms/Common Names

  • Kava-Kava resin (8CI)
  • Piper methisticum extract

Known Uses

Herbal supplement alternative to anti-anxiety drugs, used to help children with hyperactivity and as a skin-conditioning agent in cosmetics.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 2 weeks (Gavage)  (C20007)  Completed 
    •   (Peer Review Approval 01/26/2011A ) Citation: Yamashita H, Hoenerhoff MJ, Peddada SD, Sills RC, Pandiri AR. Chemical exacerbation of light-induced retinal degeneration in F344/n rats in National Toxicology Program rodent bioassays. Toxicol Pathol. 2016 Aug;44(6):892-903
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 0.125, 0.25, 0.5, 1.0, OR 2.0 G/KG; 5/SEX/SPECIES/DOSE.
  • 13 weeks (Gavage)  (C20007)  Completed 
    • Citation: Yamashita H, Hoenerhoff MJ, Peddada SD, Sills RC, Pandiri AR. Chemical exacerbation of light-induced retinal degeneration in F344/n rats in National Toxicology Program rodent bioassays. Toxicol Pathol. 2016 Aug;44(6):892-903
    • Rats: F344/N; Mice: B6C3F1/N
    • Dose: R&M: 0, 0.125, 0.25, 0.5, 1.0, OR 2.0 G/KG; R: 20/SEX/DOSE; M: 10/SEX/DOSE.

Long-Term Carcinogenicity

  • 2 years (Gavage)  (C20007)  Completed 
    •   (Peer Review Approval 01/26/2011A ) Citation: Yamashita H, Hoenerhoff MJ, Peddada SD, Sills RC, Pandiri AR. Chemical exacerbation of light-induced retinal degeneration in F344/n rats in National Toxicology Program rodent bioassays. Toxicol Pathol. 2016 Aug;44(6):892-903
    • TR-571 (NIH Number: 11-5913)  (Peer Review Approval 01/26/2011A )
      Toxicology and Carcinogenesis Studies of Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
    • Rats: F344/N; Mice: B6C3F1/N
    • Carcinogenesis Results
      • Male Rats Equivocal Evidence 
      • Female Rats No Evidence 
      • Male Mice Clear Evidence 
      • Female Mice Clear Evidence 
    • Dose: R: 0, 0.1, 0.3, OR 1.0 G/KG; M: 0, 0.25, 0.5, OR 1.0 G/KG; 50/SEX/SPECIES/DOSE.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous)  (S0828)  Completed 
    • Citation: Mathews JM, Etheridge AS, Black SR. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab Dispos. 2002 Nov;30(11):1153-7.Pubmed Abstract
    • Male Rats: F344/N
    • Dose: IV, 7 MG/KG; ORAL, 100 MG/KG.
  • Absorption Disposition Metabolism Elimination (Gavage; Intravenous; in-vitro)  (S0855)  Completed 
    • Citation: Mathews JM, Etheridge AS, Black SR. Inhibition of human cytochrome P450 activities by kava extract and kavalactones. Drug Metab Dispos. 2002 Nov;30(11):1153-7.Pubmed Abstract
    • Citation: Mathews JM, Etheridge AS, Valentine JL, Black SR, Coleman DP, Patel P, So J, Burka, LT. Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract & kavalactones in vivo & in vitro. Drug Metab Dispos. 2005 Oct; 33(10): 1555-63. Epub 2005 Jul 20.Pubmed Abstract
    • Male and Female Rats: F344/N; Human (Cell Lines)
    • Dose: 0, 1, 10, 100 uM..

Genetic Toxicology

  • Micronucleus  (A53705)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Negative 
  • Salmonella  (A00186)  Completed 
    •  Negative 
  • Salmonella  (A88186)  Completed 
    •  Negative