Testing Status of Transgenic model evaluation II (Benzene) M990069

 

CASRN: 71-43-2

Formula: C6-H6

Synonyms/Common Names

  • Benzene (Transgenic model evaluation II)
  • Phenyl hydride

Known Uses

Transgenic mouse evaluation of benzene using the p16INKa(+/-) mouse model. Benzene is used in manufacture of medicinal chemicals, dyes, organic compounds, artificial leather, linoleum, oil cloth, varnishes, lacquers, solvent for waxes, resins, oils. Used to destroy screwworm larvae in wounds-veterinary use (Merck 1989)

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 27 weeks (Gavage)  (C99034)  Subchronic Toxicology Review 
    • GMM-08 (NIH Number: 08-4425)  (Peer Review Approval 08/28/2006A )
      Toxicology and Carcinogenesis Study of Benzene (CASRN 71-43-2) in Genetically Modified Haploinsufficient p16Ink4a/p19Arf Mice (Gavage Study)
    • Mice: P16(Ink4a)/(+/-) (C57BL/6)
    • Dose: 0, 25, 50, 100, OR 200 MG/KG.