National Toxicology Program

National Toxicology Program
http://ntp.niehs.nih.gov/go/ts-m990070

Testing Status of Transgenic model evaluation II (Glycidol) - M990070

 

CASRN: 556-52-5

Formula: C3-H6-O2

Synonyms/Common Names

  • Glycidol (Transgenic model evaluation II)
  • Oxiranemethanol (9CI)

Known Uses

Transgenic mouse evaluation of glycidol using the p16INKa(+/-) mouse model. Glycidol is a viscous liquid that is used as a stabilizer in the manufacture of vinyl polymers, as an additive for oil and synthetic hydraulic fluids, and as a diluent in some epoxy resins.

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 40 weeks (Gavage)  (C99035)  Subchronic Toxicology Review 
    • GMM-13 (NIH Number: 08-5962)  (Peer Review Approval 08/28/2006A )
      Toxicology and Carcinogenesis Study of Glycidol (CASRN 556-52-5) in Genetically Modified Haploinsufficient p16Ink4a/p19Arf Mice (Gavage Study)
    • Mice: P16(Ink4a)/(+/-) (C57BL/6)
    • Dose: 0, 25, 50, 100, OR 200 MG/KG.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.