National Toxicology Program

National Toxicology Program

Testing Status of Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super®; OTNE) - M990091


CASRN: 54464-57-2

Related: 68155-66-8; 68155-67-9

Formula: C16-H26-O

Synonyms/Common Names

  • 2-Acetyloctahydro-2,3,8,8-tetramethylnaphthalene
  • Boisvelone
  • Iso-E super

Known Uses

OTNE ([1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethylnaphthalene-2yl]ethan-1-one) is the one of the major constituents of fragrance mixtures and is produced as a technical mixture (e.g., Iso E Super®). It is comprised of three primary isomers: CASRN 54464-57-2 "beta isomer" - the major component (40-60%) of most commercial mixtures, CASRN 68155-66-8 "gamma isomer" and CASRN 68155-67-9 "alpha isomer."

Chemical Properties

Toxicity Effects (HSDB)

Short-Term Toxicity

  • 13 weeks (Topical Application)  (C20307)  Completed 
    • TOX-92 (NIH Number: 16-5940)
      NTP Technical Report on the Toxicity Studies of Octahydro-tetramethyl-naphthalenyl-ethanone (OTNE) Administered Dermally to F344/NTac Rats and B6C3F1/N Mice
    • Rats: F344/NTac; Mice: B6C3F1
    • Dose: 0, 6.25:93.75, 12.5:87.5, 25:75, 50:50, or 100:0; 10/sex/species.

Special Studies

  • Absorption Disposition Metabolism Elimination (Gavage)  (S0876)  Completed 
    • Citation: Final Study Report Disposition and Metabolism of [14C]Iso E Super in Rats and Mice Following Dermal, Oral and Intravenous Exposure CAS #: 54464-57-2 Studies of Chemical Disposition in Mammals May 31, 2007
    • Male Rats: F344/N; Female Mice: B6C3F1
    • Dose: 20, 30 MG/KG..

Genetic Toxicology

  • Micronucleus  (F28470)  Completed 
    • Rats: F344/NTac
    • Male Negative 
    • Female Negative 
  • Micronucleus  (F35719)  Completed 
    • Mice: B6C3F1
    • Male Negative 
    • Female Equivocal 
  • Salmonella  (A39068)  Completed 
    •  Negative 
  • Salmonella  (G99091)  Completed 
    •  Negative 

Organ Systems Toxicity

  • varies Immunotoxicity (Topical Application)  (IMM20702)  Completed 
    • Female Mice: BALB/c
    • Dose: 0, 1, 2.5, 5, 10, or 20%.
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.