Management Status Report: Reference 17

Long-Term Exposure Studies for Which Technical Reports Were Not Prepared
CHEMICAL NAME
SYNONYM(S)
PRIMARY
CASRN
USE ROUTE SPECIES COMMENTS FOOTNOTE
REFERENCE
Actinomycin D
Actinomycin C1
50-76-0 CMOT/NATL IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Agaritine
5-(2-(4-Hydroxymethyl)phenyl)hydrazide)-L-Glutamic acid (9CI)
2757-90-6 CMOT/NATL WATER M4 RESULTS REPORTED IN JOURNAL ARTICLE E
3-Amino-9-ethylcarbazole
9-Ethyl-9H-carbazol-3-amine
132-32-1 DYE FEED R2 M3
Amsacrine
Acridinylanisidide
N-(4-(9-Acridinylamino)-3-methoxyphenyl)methanesulfonamide
51264-14-3 CMOT/SYN IP/IJ R2 M3
L-Arginine Glutamate
L-Arginine L-glutamate
L-Glutamic acid compd. with L-Arginine (1:1)
Modumate
4320-30-3 NATL FEED R2 M1
Azathioprine
NSC 39084
446-86-6 PHAR/SYN IP/IJ R8 M4 A
Benzyl chloride
(Chloromethyl)benzene
100-44-7 INTR/SYN GAV R2 M3 H
1,3-bis(Chloroethyl)-1-nitrosourea
BCNU
NSC 409962
154-93-8 CMOT IP/IJ R8 M4 A
bis(Chloromethyl) ether
Oxybis(chloromethane)
542-88-1 INTR INHAL R8 H1
1,3-Butadiene
alpha,gamma-Butadiene
106-99-0 INTR/N/S INHAL M3 Q
Calcium chromate
Chromic acid (H2CrO4), calcium salt (1:1)
13765-19-0 INTR/SYN INHAL R8 H1
Carbon tetrachloride
Benzinoform
Freon 10
Halon 1040
Tetrachloromethane
56-23-5 INTR/SYN GAV R1 M3
Chlorambucil
4-(Bis(2-chloroethyl)amino)benzenebutanoic acid
305-03-3 CMOT/SYN IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Chloromethyl methyl ether
Chloromethoxymethane
107-30-2 INTR/SYN INHAL R8 H1
Chromium
Chrome
Chromium Inorganic, Hexavalent
7440-47-3 INTR/NATL INHAL R8 H1
Cyclohexanone
Pimelin ketone
108-94-1 SOLV/SYN WATER R2 M3 J
Cyclophosphamide
N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide
50-18-0 CMOT/SYN IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Cytarabine
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
Cytosine arabinoside
147-94-4 PHAR/SYN IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Cytoxal alcohol
Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, compd .with cyclohex anamine (1:1) (9CI)
4465-94-5 CMOT IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Dacarbazine
DIC
1H-Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-
4342-03-4 CMOT/SYN IP/IJ R8 M4 A
Daunomycin
Rubomycin C
20830-81-3 CMOT/NATL IP/IJ R8 M4 A
o,p'-DDD
1-Chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)benzene
o,p'-Dichlorodiphenyldichloroethane
53-19-0 PEST/SYN IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Dibromodulcitol
1,6-Dibromo-1,6-dideoxy-D-galactitol
10318-26-0 CMOT/SYN IP/IJ R8 M4 A
Dibromomannitol
1,6-Dibromo-1,6-dideoxy-D-mannitol
488-41-5 CMOT/SYN IP/IJ R8 M4 A
Dichloromethotrexate
N-(3,5-Dichloro-4-((2,4-diamino-6-pteridinylmethyl)methylamino)benzoyl)glutamic acid
528-74-5 CMOT IP/IJ R8 M4 A
Dimethylcarbamoyl chloride
Carbamic chloride, dimethyl-
Dimethylcarbamyl chloride
79-44-7 INTR INHAL R8 H1
Dimethyl hydrazine (DMH)
Hydrazine, 1,1-dimethyl-
57-14-7 FUEL/SYN INHAL M1
1,2-Dimethylhydrazine 2HCl
N,N'-Dimethylhydrazine dihydrochloride
306-37-6 FUEL FEED R2
Epichlorhydrin
alpha-Epichlorohydrin
Oxirane, (chloromethyl)-
106-89-8 INTR/SYN INHAL R8
Furan
Oxacyclopentadiene
110-00-9 DTRG/N/S GAV RC 9/12/16 is the actual date that the final NCTR report was sent to Nigel. There may still be a publication at a later date, but I don’t have a date for it as of yet. Please let me know if you need anything else. Amy Changed status to complete-sl 10/20/16
Guanazole
1H-1,2,4-triazole-3,5-diamine (9CI)
1455-77-2 CMOT IP/IJ R8 M4 A
Hexanamide
N-Hexamide
628-02-4 INTR FEED R2 M1
Hydroxyurea
SQ 1089
127-07-1 CMOT/SYN IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Lomustine
N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea (9CI)
13010-47-4 CMOT/SYN IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Melphalan
4-(Bis(2-chloroethyl)amino)-DL-phenylalanine
148-82-3 CMOT/SYN IP/IJ R8 M4 A
6-Mercaptopurine
1,7-Dihydro-6H-purine-6-thione (9CI)
50-44-2 CMOT/SYN IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Merphalan
4-(Bis(2-chloroethyl)amino)-DL-phenylalanine
531-76-0 CMOT IP/IJ R8 M4 A
Methapyrilene hydrochloride
1,2-Ethanediamine, N,N-dimethyl-N'-2-pyridinyl-N'-(2-thienylmethyl)-, monohydrochloride (9 CI)
135-23-9 PHAR/SYN FEED R2 M3 RESULTS REPORTED IN JOURNAL ARTICLE F
Methotrexate
N-(4-(((2,4-Diamino-6-pteridinyl)methyl)methylamino)benzoyl)-L-glutamic acid (9CI)
59-05-2 CMOT/SYN IP/IJ R8 M4 A
Methyl CCNU
N-(2-Chloroethyl)-N'-(4-methylcyclohexyl)-N-nitrosourea (9CI)
(1-Nitrosourea-1-(2-chloroethyl)-3-(4-methylcyclohexyl)
13909-09-6 CMOT IP/IJ R8 M4 A
Methyl isocyanate
Isocyanatomethane (9CI)
624-83-9 INTR/SYN INHAL NA R
6-Methylmercaptopurine ribonucleoside
6-(Methylthio)-9-beta-D-ribofuranosyl-9H-purine
342-69-8 CMOT IP/IJ R8 M4 A
2-Methyl-1-nitroanthraquinone
2-Methyl-1-nitro-9,10-Anthracenedione (9CI)
129-15-7 INTR/SYN FEED M3 D
Mitomycin C
Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1 ,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methyl-, (1aS-(1aalpha,8beta,8aalpha,8balpha))- (9CI)
50-07-7 CMOT/N/S IP/IJ R8 M4 A
Mouse ageing study
MOUSEAGE M3 RESULTS REPORTED IN JOURNAL ARTICLE O
Nitrofurazone
2((5-Nitro-2-furanyl)methylene)hydrazinecarboxamide
59-87-0 PHAR/SYN FEED M3
NTP 90 diet study
DIET90 FEED/SYN FEED M3 NA N
NTP 91/92 diet study
DIET9192 FEED/SYN FEED R2 N
Polyurethane
Urethane polymers
9009-54-5 RUBR INHAL R8 H1
Prednisone
Deltacortisone
17,21-Dihydroxy-pregna-1,4-diene-3,11,20-trione (9CI)
53-03-2 CMOT/N/S IP/IJ R8 M4 A
Procarbazine hydrochloride
Natulan hydrochloride
N-(1-Methylethyl)-4-((2-methylhydrazino)benzamide monohydrochloride (9CI)
366-70-1 CMOT/SYN IP/IJ R8 M4 A
Rotenone
(2R-(2-alpha,6Aalpha,12Aalpha))-1,2,12,12A-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-(1 )benzopyrano(3,4-B)furo(2,3-H)(1)benzopyran-6(6aH)-one (9CI)
83-79-4 PEST/NATL IP/IJ R2 RESULTS REPORTED IN NCTR REPORT M
Sodium Fluoride
Sodium fluoride (NaF)
7681-49-4 ADHS/N/S WATER R2 Supplemental study P
Streptozotocin
2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucose (9CI)
Streptozoticin
18883-66-4 CMOT/NATL IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Styrene oxide
Phenyloxirane (9CI)
96-09-3 INTR GAV R2 M3 RESULTS REPORTED IN JOURNAL ARTICLE K
p-Tolylurea
(4-Methylphenyl)urea (9CI)
622-51-5 LABC FEED R2 M1
Uracil mustard
5-(Bis(2-chlorethyl)amino)-2,4(1H,3H)pyrimidinedione (9CI)
66-75-1 CMOT/SYN IP/IJ R8 M4 A
Vinblastine
Vincaleukoblastine (9CI)
865-21-4 CMOT/NATL IP/IJ R8 M4 RESULTS REPORTED IN JOURNAL ARTICLE A
Vincristine
22-Oxovincaleukoblastine (9CI)
57-22-7 CMOT/NATL IP/IJ R8 M4 A
Wollastonite calcium silicates
Wollastonite (9CI)
13983-17-0 PNT/NATL INHAL R2 RESULTS REPORTED IN JOURNAL ARTICLE I
A
EK Weisburger, Bioassay Program for Carcinogenic Hazards of Cancer Chemotherapeutic Agents. Cancer 40:1935-1949 (1977)
D
ASK Murthy, JR Baker, ER Smith, GG Wade, Development of Hemangiosarcomas in B6C3F1 Mice Fed 2-Methyl-1-Nitroanthraquinone. Int. J. Cancer 19:117-121 (1977)
E
B Toth, CR Raha, L Wallcave, D Nagel, Attempted Tumor Induction with Agaritine in Mice. Anticancer Res 1:255-258 (1981)
F
W Lijinsky, MD Reuber, BN Blackwell, Liver Tumors Induced in Rats by Oral Administration of the Antihistaminic Methapyrilene Hydrochloride. Science 209:817-819 (1980)
H
W Lijinsky, Chronic Bioassay of Benzyl Chloride in F344 Rats and (C57BL/6JXBALB/C)F1 Mice. J Natl Cancer Inst. 1986 Jun;76(6):1231-6.
I
McConnell EE, Hall L, Adkins B Jr., Studies on the Chronic Toxicity (Inhalation) of Wollastonite in Fischer 344 Rats. Inhalation Toxicology 3:323-337 (1991).
J
Lijinsky W, RM Kovatch, Chronic Toxicity Study of Cyclohexanone in Rats and Mice. J Natl Cancer Inst. 1986 Oct;77(4):941-9.
K
W Lijinsky. Rat and Mouse Forestomach Tumors Induced by Chronic Oral Administration of Styrene Oxide. J Natl Cancer Inst. 1986 Aug;77(2):471-6.
M
Tumorogenic Potential of Rotenone and its Specificity for Mammary Tissue, published by National Center for ToxicologicalResearch (NCTR Experiment No. 216). Call NCTR (501-543-7115) for availability of document.
N
GN Rao, J Edmondson and MR Elwell. Influence of dietary fat and fiber on growth and tumor incidences in Fischer 344 rats (presented in an abstract at the 33rd annual meeting of the Society of Toxicology in March 1994). Toxicologist 14(1):303, 1994.
O
GN Rao. Growth, Body Weight Patterns, and life Span of the B6C3F1 Mouse. Pathology of the Mouse (R. Maronpot, Ed.) Cache River Press, Vienna, IL. (1999)
P
Supplemental 2-Year Sodium Fluoride Male Rat Study (available on NTP website http://ntp.niehs.nih.gov/go/16389)
Q
Bucher JR, Melnick RL, and Hildebrandt PK. Lack of Carcinogenicity in Mice Exposed Once to High Concentrations of 1,3-Butadiene. J. Nat. Cancer Inst 85: 1866-1867 (1993).
R
Bucher JR, Uraih LC, Hildebrandt PK, Sauer RM and Seely JC. Carcinogenicity and Pulmonary Pathology Associated with a Single 2-Hour Inhalation Exposure of Laboratory Rodents to Methyl Isocyanate. J. Nat. Cancer Inst 81:1586-1587 (1989).