Report Date: Oct. 16, 1987
The following abstract presents results of a study conducted by a contract laboratory for the National Toxicology Program. The findings may not have been peer reviewed and were not evaluated in accordance with the levels of evidence criteria established by NTP in March 2009. For more information, see the Explanation of Levels of Evidence for Developmental Toxicity. The findings and conclusions for this study should not be construed to represent the views of NTP or the U.S. Government.
Ethylene glycol diethyl ether, a member of the glycol ether class of industrial solvents, was evaluated for toxic and teratogenic effects in timed-pregnant New Zealand White rabbits. Animals were exposed to EGDE in water, by gavage on gestational days 6 through 19 and sacrificed on gd 30. Prior to initiation of the teratology study, a preliminary study was conducted in order to establish appropriate doses for use in the teratology study. Based on the results of the preliminary study, doses of 0, 25, 50 and 100 mg/kg/day EGDE were administered in the teratology study.
The teratology study was conducted using a three replicate design, with 12-14 animals assigned to each dose group in each replicate. A total of 26-32 does (i.e., confirmed-pregnant females) per treatment group were evaluated in the study, with the following results:
In conclusion, exposure of timed-pregnant New Zealand White rabbits to EGDE during gestation resulted in clearcut evidence of developmental toxicity at doses of 50 mg/kg/day and above, in the absence of clearcut maternal toxicity.