Species: Rats, mice
NTP has developed a range of techniques and testing regimens for evaluating the potential of environmental and occupational substances to damage the immune system.
NTP evaluates the potential toxic effects of exposure to substances on the immune system. These materials may include:
- Food additives
- Natural products such as mycotoxins
- Products used in the pharmaceutical, farming, chemical, or consumer product industries
Immunotoxicity tests are designed to evaluate immune function and hypersensitivity. These tests are carried out using rodent models, cultured mammalian cells, and other in vitro methods.
Levels of Evidence Criteria
Levels of Evidence for Immunotoxicity
NTP describes the results of individual studies for test substances, and notes the strength of the evidence for conclusions regarding each study. Evaluation of immune system effects are based on the NTP Criteria for Levels of Evidence for Immune System Toxicity. The Levels of Evidence are divided into five categories.
Categories for positive experimental results:
Clear Evidence of Immune System Toxicity
Some Evidence of Immune System Toxicity
Category for uncertain experimental results:
Equivocal Evidence of Immune System Toxicity
Category for no observable effects:
No Evidence of Immune System Toxicity
Category for experiments that cannot be evaluated because of major flaws:
Inadequate Study of Immune System Toxicity
Specifications & Guidance
Abstracts & Reports
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|Abstract||Full Text||Report Title||Year||Type|
|IMM-01||Not yet available||Immunotoxicity of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) Administered in Female BALB/c Mice - In progress.||N/A||Immunotoxicity|