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https://ntp.niehs.nih.gov/go/imm

Immunotoxicity

Plasma cells segregating antibodies to destroy viruses

Study Overview

Study: Immunotoxicity
Species: Rats, mice

Description

NTP has developed a range of techniques and testing regimens for evaluating the potential of environmental and occupational substances to damage the immune system.

Immunotoxicity Studies

NTP evaluates the potential toxic effects of exposure to substances on the immune system. These materials may include:

  • Food additives
  • Natural products such as mycotoxins
  • Products used in the pharmaceutical, farming, chemical, or consumer product industries

Immunotoxicity tests are designed to evaluate immune function and hypersensitivity. These tests are carried out using rodent models, cultured mammalian cells, and other in vitro methods.

Levels of Evidence Criteria

Levels of Evidence for Immunotoxicity

NTP describes the results of individual studies for test substances, and notes the strength of the evidence for conclusions regarding each study. Evaluation of immune system effects are based on the NTP Criteria for Levels of Evidence for Immune System Toxicity. The Levels of Evidence are divided into five categories.

Categories for positive experimental results:

Clear Evidence of Immune System Toxicity
Some Evidence of Immune System Toxicity

Category for uncertain experimental results:

Equivocal Evidence of Immune System Toxicity

Category for no observable effects:

No Evidence of Immune System Toxicity

Category for experiments that cannot be evaluated because of major flaws:

Inadequate Study of Immune System Toxicity

Specifications & Guidance

Abstracts & Reports

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Abstracts and Reports for Immunotoxicity
Abstract Full Text Report Title Year Type
IMM-01 Not yet available Immunotoxicity of 4-Methylcyclohexanemethanol (CASRN 34885-03-5) Administered in Female BALB/c Mice - In progress. N/A Immunotoxicity