NTP's Modified One-Generation (MOG) Reproduction Study design evolved from:
The classical study used to evaluate reproductive toxicity is the multigenerational reproduction experimental design. NTP has modified this classical study design to better utilize the animals produced and to reduce animal use by improved experimental design and statistical power.
NTP's Modified One-Generation Reproductive study design employs pregnant animals with dosing beginning at implantation and continued dosing of the dams throughout gestation and lactation. At weaning the offspring are administered the test article at the same dose level as their respective dam and are subsequently assigned to a number of different cohorts normally including:
NTP's Modified One-Generation Study emphasizes a full evaluation of the F1 generation animals and uses fewer animals than the classical multigeneration study design, while generating information on the effects of agents on prenatal development, postnatal development, and reproduction.
For further design details, see the MOG Protocol template.