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Organ Systems Toxicity

Prenatal Developmental Toxicity Study

The prenatal developmental toxicity study (also known as embryo-fetal developmental study, teratology study, or Segment II study) is undertaken to identify chemicals that may pose a risk to the developing fetus if pregnant women are exposed. The results of well-conducted animal studies are used by regulatory agencies to help set human exposure guidelines.

Immunology

Immunotoxicology is the study of adverse effects on the immune system resulting from occupational, inadvertent, or therapeutic exposure to chemical or biologic materials. These materials may include products or by-products used in the pharmaceutical, farming, chemical, as well as consumer product industries, food additives, or natural products such as mycotoxins.

Modified One-Generation

The classical study used to evaluate reproductive toxicity is the multigenerational reproduction experimental design. NTP has modified this classical study design to better utilize the animals produced and to reduce animal use by improved experimental design and statistical power.

Neurobehavioral Toxicity

NTP has developed a range of approaches and testing regimens for evaluating potential toxic effects of exposure to environmental and occupational substances on the nervous system. These studies are carried out through the use of rodent models. Tests include evaluations of motor activity, startle response and learning and memory.

Reproductive

NTP has developed a range of techniques and testing regimes for evaluating the potential toxic effects of exposure to environmental and occupational substances on the reproductive system. These studies are carried out primarily through the use of rodent models.