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Organ Systems Toxicity

Plasma cells segregating antibodies to destroy viruses

Study Overview

Study: Organ systems toxicity, immunotoxicology, neurobehavioral toxicity
Species: Rats, mice

Description

NTP has developed a range of techniques and testing regimens for evaluating the potential of environmental and occupational substances to damage organ systems. Testing is focused on the following areas of study:

Immunotoxicity Studies 

NTP evaluates the potential toxic effects of exposure to substances on the immune system. These materials may include:

  • food additives
  • natural products such as mycotoxins
  • or products used in the pharmaceutical, farming, chemical, or consumer product industries

Immunotoxicity tests are designed to evaluate immune function and hypersensitivity. These tests are carried out using rodent models.

Neurotoxicity Studies

NTP has developed a range of approaches and testing regimens for evaluating potential toxic effects of exposure to environmental and occupational substances on the nervous system. These studies are carried out using rodent models. Tests include evaluations of motor activity, startle response, and learning and memory.

Levels of Evidence Criteria

Levels of Evidence for Immunotoxicity

NTP describes the results of individual studies for test substances, and notes the strength of the evidence for conclusions regarding each study. Evaluation of immune system effects are based on the NTP Criteria for Levels of Evidence for Immune System Toxicity. The Levels of Evidence are divided into five categories.

Category for positive experimental results:

Clear Evidence of Immune System Toxicity
Some Evidence of Immune System Toxicity

Category for uncertain experimental results:

Equivocal Evidence of Immune System Toxicity

Category for no observable effects:

No Evidence of Immune System Toxicity

Category for experiments that cannot be evaluated because of major flaws:

Inadequate Study of Immune System Toxicity

Specifications & Guidance

Abstracts & Reports

The following list of abstracts represents studies conducted by NTP between 1985 and 2012. These studies have not been evaluated by the levels of evidence criteria established by NTP on March 2009. Because this list may not be totally comprehensive, contact CDM (or use our contact form) to inquire about other studies.

Note on Accessibility: Persons with disabilities or using assistive technology may find some documents are not fully accessible. For assistance, contact CDM (or use our contact form) and identify the documents/pages for which access is required. We will assist you in accessing the content of these files. NIEHS has helpful information on accessibility.

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Listing of all NTP immunotoxicity abstracts
Abstract Full Text Report Title Report Year Type
IMM92039 N/A NTP Report on the Assessment of Contact Hypersensitivity to Alachlor in Female B6C3F1 Mice (dermal studies) (CASRN: 15972-60-8) 1993 Immunotoxicity
IMM89025 N/A NTP Report on the Immunotoxicity of Aldicarb Oxime (CAS No. 1646-75-9) in Female B6C3F1 Mice (immune modulation studies) N/A Immunotoxicity
IMM20302 N/A NTP Report on the Assessment of Contact Hypersensitivity to 5-Amino-O-Cresol in BALB/c Female Mice (dermal studies) (CASRN: 2835-95-2) 2006 Immunotoxicity
IMM20405 N/A NTP Report on the Assessment of Contact Hypersensitivity to Annatto in Female BALB/c Mice (dermal studies) (CAS No. 1393-63-1) 2008 Immunotoxicity
IMM94003 N/A NTP Report on the Dose Range-Finding Study for the Immunotoxicity Evaluation of Atrazine (CAS No. 1912-24-9) in Female B6C3F1 Mice N/A Immunotoxicity
IMM94002 N/A NTP Report on the Immunotoxicity of Atrazine (CAS No. 1912-24-9) in Female B6C3F1 Mice 1994 Immunotoxicity
IMM95006 N/A NTP Report on the Assessment of Contact Hypersensitivity to Atrazine in Female B6C3F1 Mice (dermal studies) (CASRN: 1912-24-9) 1994 Immunotoxicity
IMM96003 N/A NTP Report on the Immunotoxicity of 3'-Azido-3'-deoxythymidine (AZT) (CAS No. 30516-87-1) in Female B6C3F1 1 Mice. 2000 Immunotoxicity
IMM20401 N/A NTP Report on the Developmental Immunotoxicology Evaluation of 3'-Azido-3'-deoxythymidine in Female B6C3F1 Mice (CASRN: 30516-87-1) 2012 Immunotoxicity
IMM20306 N/A NTP Report on the Immunotoxicity of 3'-Azido-3'-deoxythymidine in Female B6C3F1/N Mice (CASRN: 30516-87-1) (28 days) 2012 Immunotoxicity
IMM97010 N/A NTP Report on the Assessment of Contact Hypersensitivity to Azithromycin in BALB/c Female Mice (CASRN: 83905-01-5) 1998 Immunotoxicity
IMM89007 N/A NTP Report on the Immunotoxicity of Benzethonium Chloride (CAS No. 121-54-0) in Female B6C3F1 Mice (contact hypersensitivity studies) N/A Immunotoxicity
IMM89037 N/A NTP Report on the Assessment of Contact Hypersensitivity to o-Benzyl-P-Chlorophenol in Female B6C3F1 Mice (CASRN: 120-32-1) 1990 Immunotoxicity
IMM20504 N/A NTP Report on the Assessment of Contact Hypersensitivity to cis-Bixin in Female BALB/c Mice (CASRN: 6983-79-5) 2008 Immunotoxicity
I00058 N/A NTP Report on the Immunotoxicity of Black Cohosh in Female B6C3F1/N Mice - Range-Finding Report (CASRN: 84776-26-1) 2012 Immunotoxicity
I05054 N/A NTP Report on the Immunotoxicity evaluations of samples from male and female Harlan Sprague Dawley rats exposed to blasting sand by inhalation for up to 39 weeks 2012 Immunotoxicity
IMM95005 N/A NTP Report on the Assessment of Contact Hypersensitivity to Buty Acrylate in Female B6C3F1 Mice (CASRN: 141-32-2) 1994 Immunotoxicity
IMM20605 N/A NTP Report on the Assessment of Contact Hypersensitivity to tert-Butyl Hydroperoxide in Female BALB/c Mice (CASRN: 75-91-2) 2010 Immunotoxicity
IMM94001 N/A NTP Report on the Immunotoxicity of Carbon Tetrachloride (CAS No. 56-23-5) in Female B6C3F1 Mice 1994 Immunotoxicity
IMM91021 N/A NTP Report on the Dose Range-Finding Study for the Immunotoxicity Evaluation of Carbon Tetrachloride (CAS No. 56-23-5) in Female B6C3F1 Mice 1994 Immunotoxicity
IMM20007 N/A NTP Report of the Immunotoxicity of Chloramine (CAS No. 10599-90-3) in Female B6C3F1 Mice 2004 Immunotoxicity
IMM98002 N/A NTP Range-Finding Report on Immunotoxicity of Chloroform in Female B6C3F1 Mice (CASRN: 67-66-3) 2006 Immunotoxicity
IMM87099 N/A NTP Report on the Immunotoxicity of 4-Chloro-o-phenylenediamine (CAS No. 95-83-0) in Female B6C3F1 Mice 1987 Immunotoxicity
IMM89029 N/A NTP Assessment of Contact Hypersensitivity of 4-Chloro-o-phenylenediamine (CAS No. 95-83-0) in Female B6C3F1 Mice 1987 Immunotoxicity
IMM95001 N/A NTP Report on the Immunotoxicity of Chlorpyrofos in Female B6C3F1 Mice (Contact Hypersensitivity Studies) (CASRN: 2921-88-2) 1994 Immunotoxicity
IMM97007 N/A NTP Report on the Immunotoxicity of Clarithromycin (CAS No. 81103-11-9) in Female B6C3F1 Mice 2000 Immunotoxicity
IMM97009 N/A NTP Report on the Immunotoxicity of Clarithromycin (CAS No. 81103-11-9) in Female BALB/c Mice 1997 Immunotoxicity
IMM20710 N/A NTP Report on the Assessment of Contact Hypersensitivity to o-Cresol in Female BALB/c Mice (CASRN: 95-48-7) 2010 Immunotoxicity
IMM88035 N/A NTP Report on the Assessment of Contact Hypersensitivity to Crotonaldehyde in Female B6C3F1 Mice (CASRN: 4170-30-3) 1989 Immunotoxicity
IMM96014 N/A NTP Report on the Immunotoxicity Evaluation of Cyclosporin A (CAS No. 59865-13-3) in Female C57BL/6 Mice 1996 Immunotoxicity
IMM90015 N/A NTP Report on the Immunotoxicity of Dapsone (CAS No. 80-08-0) in Female C57BL/6 Mice (immune modulation studies) 1991 Immunotoxicity
IMM90015 N/A NTP Report on the Immunotoxicological Effects of Dapsone after 30 Days Oral Exposure in C57BL/6 Mice (CASRN: 80-08-0) 1991 Immunotoxicity
IMM20602 N/A NTP Report on the Assessment of Contact Hypersensitivity to 2,3-Butanedione (Diacetyl) in Female BALB/c Mice (CASRN: 431-03-8) 2012 Immunotoxicity
IMM87034 N/A NTP Report on the Immunotoxicity of 2,4-Diaminotoluene (CAS No. 95-80-7) in Female B6C3F1 Mice (gavage studies) 1987 Immunotoxicity
IMM92040 N/A NTP Report on the Assessment of Contact Hypersensitivity to 2,4-Diaminotoluene in Female B6C3F1 Mice (dermal studies) (CASRN: 95-80-7) 1990 Immunotoxicity
IMM20506 N/A NTP Range-Finding Report: Immunotoxicity of 1,2:5,6-Dibenzanthracene in Female B6C3F1/N Mice (CASRN: 53-70-3) 2012 Immunotoxicity
IMM20607 N/A NTP Report on the Immunotoxicity of 1,2:5,6-Dibenzanthracene in Female B6C3F1/N Mice (CASRN: 53-70-3) 2012 Immunotoxicity
IMM20507 N/A NTP Report on the Developmental Immunotoxicology Evaluation of 1,2:5,6-Dibenzanthracene in Female B6C3F1 Mice (CASRN: 53-70-3) 2012 Immunotoxicity
IMM98001 N/A NTP Report on the Immunotoxicity of Dibromoacetic Acid (CAS No. 631-64-1) in Female B6C3F1 Mice (Dose Range-Finding Report) N/A Immunotoxicity
I96093 N/A NTP Report on the Immunotoxicity of Dibromoacetic acid in Female Female Sprague Dawley Rats (CASRN: 631-64-1) 2012 Immunotoxicity
IMM98001 N/A NTP Range-Finding Report: Immunotoxicity of Dibromoacetic Acid in Female B6C3F1 Mice (CASRN: 631-64-1) 1999 Immunotoxicity
IMM99001 N/A NTP Report on the Immunotoxicity of Dibromoacetic Acid in Female B6C3F1 Mice (CASRN: 631-64-1) 2006 Immunotoxicity
IMM20501 N/A NTP Range-Finding Report: Immunotoxicity of Dibromoacetic acid in Female Sprague Dawley Rats (CASRN: 631-64-1) 2006 Immunotoxicity
I10324 N/A NTP Range-Finding Report Immunotoxicity of 2,3,7-Tribromodibenzo-p-dioxin and 2,3-Dibromo-7,8-dichlorodibenzo-p-dioxin (CASRN: 51974-40-4 and 50585-40-5) 2012 Immunotoxicity
I10325 N/A NTP Range-Finding Report Immunotoxicity of 2,3,7-Tribromodibenzo-p-dioxin and 2,3-Dibromo-7,8-dichlorodibenzo-p-dioxin (CASRN: 51974-40-4 and 50585-40-5) 2012 Immunotoxicity
IMM98003 N/A NTP Report on the Immunotoxicity of Dichloroacetic Acid (CAS No. 79-43-6) in Female B6C3F1 Mice 2002 Immunotoxicity
IMM96015 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dicyclohexylcarbodiimide (CAS No. 538-75-0) in B6C3F1 Female Mice N/A Immunotoxicity
IMM20201 N/A NTP Range-Finding Report: Immunotoxicity of 1,3-Dichloropropene (Telone II) in Female B6C3F1 Mice (CASRN: 542-75-6) 2012 Immunotoxicity
IMM89060 N/A NTP Report on the Immunological Evaluation of 2',3'-Dideoxyadenosene (ddA) (CAS No. 4097-22-7) Effect on LP-BM5 (MAIDS) Infection in Female C57BL/6 Mice 1989 Immunotoxicity
IMM90014 N/A NTP Report on the Immunotoxicity of 2',3'-Dideoxyadenosine (ddA) (CAS No. 4097-22-7) in Female C57BL/6 Mice (immune modulation studies) 1989 Immunotoxicity
IMM94006 N/A NTP Report on the Immunotoxicity of 2',3'-Dideoxyinosine (ddI) (CAS No. 69655-05-6) in Female B6C3F1 Mice 1996 Immunotoxicity
IMM96001 N/A NTP Range-Finding Report on the Immunotoxicity of 2',3'-Dideoxyinosine (ddI) in Female B6C3F1 Mice (CASRN: 69655-05-6) 1995 Immunotoxicity
IMM90016 N/A NTP Report on the Immunotoxicity of 2'3'-Dideoxydidehydrothymidine (D4T) (CAS No. 3056-17-5) in C57BL/6 AND DBA/2 Mice (immune modulation studies) 1990 Immunotoxicity
IMM20004 N/A RNTP Dose Range-Finding Study for Immunological Evaluation of Diethanolamine in Female B6C3F1 Mice (CASRN: 111-42-2) 1992 Immunotoxicity
IMM98011 N/A NTP Report on the Immunotoxicity of Diethanolamine (CAS No. 111-42-2) in Female B6C3F1 Mice N/A Immunotoxicity
IMM20303 N/A NTP Report on the The Immunotoxicity of Diethanolamine (CAS No. 111-42-2) in Female Fischer 344 Rats 1992 Immunotoxicity
IMM95010 N/A NTP Report on the Assessment of Contact Hypersensitivity to Diisopropylcarbodiimide in Female B6C3F1 Mice (CASRN: 693-13-0) 1995 Immunotoxicity
I07051 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dimethylamine Borane in Female BALB/c Mice (CASRN: 74-94-2) 2012 Immunotoxicity
IMM98008 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dinitrochlorobenzene (CASRN: 97-00-7), Potassium Dichromate (CASRN: 7778-50-9) and Methyl Salicylate (CASRN: 119-36-8) in BALB/c Female Mice 1997 Immunotoxicity
IMM98006 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dinitrochlorobenzene (CASRN: 97-00-7), Potassium Dichromate (CASRN: 7778-50-9) and Methyl Salicylate (CASRN: 119-36-8) in BALB/c Female Mice 1997 Immunotoxicity
IMM98007 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dinitrochlorobenzene (CASRN: 97-00-7), Potassium Dichromate (CASRN: 7778-50-9) and Methyl Salicylate (CASRN: 119-36-8) in BALB/c Female Mice 1997 Immunotoxicity
IMM20403 N/A NTP Range-Finding Report - Immunotoxicity of Disulfoton in Female B6C3F1 Mice (CASRN: 298-04-4) 2009 Immunotoxicity
IMM20101 N/A NTP Range-Finding Report - Immunotoxicity of Echinacea Purpurea in Female B6C3F1 Mice (CASRN: 90028-20-9) 2012 Immunotoxicity
IMM20104 N/A NTP Report on the Immunotoxicity of Echinacea Purpurea in Female B6C3F1/N Mice (CASRN: 90028-20-9) 2012 Immunotoxicity
IMM20404 N/A NTP Range-Finding and Immunotoxity of Elmiron® in Female B6C3F1 Mice (CASRN: 37319-17-8) 2012 Immunotoxicity
IMM20502 N/A NTP Range-Finding and Immunotoxity of Elmiron® in Female B6C3F1 Mice (CASRN: 37319-17-8) 2012 Immunotoxicity
IMM95004 N/A NTP Report on the Assessment of Contact Hypersensitivity to Ethyl Acrylate in Female B6C3F1 Mice (CASRN: 140-88-5) 1994 Immunotoxicity
IMM90009 N/A NTP Report on the Immunotoxicity of Ethylene Thiourea (CAS No. 96-45-7) in Female B6C3F1 Mice (contact hypersensitivity studies) N/A Immunotoxicity
IMM91018 N/A NTP Report on the Immunotoxicity of Ethylenediamine in Female B6C3F1 Mice (Contact Hypersensitivity Studies) (CASRN: 107-15-3) 1992 Immunotoxicity
I20239 N/A NTP Report of the Assessment of Contact Hypersensitivity to 2-Ethylhexyl p-methoxycinnamate in Female BALB/c Mice (CASRN: 5466-77-3) 2012 Immunotoxicity
IMM91024 N/A NTP Report on the Immunotoxicity of Fluconazole (FLU) (CAS No. 86386-73-4) in Female B6C3F1 Mice 1992 Immunotoxicity
I20407B N/A NTP Range-Finding Report: Immunotoxicity of C60 Fullerene in Female B6C3F1 Mice (CASRN: 99685-96-8) 2012 Immunotoxicity
I20710B N/A NTP Range-Finding Report: Immunotoxicity of C60 Fullerene in Female B6C3F1 Mice (CASRN: 99685-96-8) 2012 Immunotoxicity
I20407 N/A NTP Range-Finding Report: Immunotoxicity of C60 Fullerene in Female Wistar Han Rats (CASRN: 99685-96-8) 2012 Immunotoxicity
I20710 N/A NTP Range-Finding Report: Immunotoxicity of C60 Fullerene in Female Wistar Han Rats (CASRN: 99685-96-8) 2012 Immunotoxicity
IMM90013 N/A NTP Report on the Immunotoxicity of Gallium Arsenide (CAS No. 1303-00-0) in Female B6C3F1 Mice (immune modulation studies) 1987 Immunotoxicity
MG96005 N/A NTP Assessment of the Immunotoxicity of Genistein (Endocrine Disruptor) (CAS No. 446-72-0) in Male and Female Sprague-Dawley Rats 1998 Immunotoxicity
IMM20705 N/A NTP Report on the Assessment of the Ability of Genistein to Modulate Type 1 Diabetes in Female Non-Obese Diabetic (NOD) Mice (CASRN: 446-72-0) 2012 Immunotoxicity
IMM87098 N/A NTP Report on the Contact Hypersensitivity Response to Glutaraldehyde (CASRN: 111-30-8) 1986 Immunotoxicity
IMM20701 N/A NTP Range-Finding Report - Immunotoxicity of Gugulipid® 2.5% Granules (Gum Guggul Extract) in Female B6C3F1 Mice 2011 Immunotoxicity
IMM20002 N/A NTP Dose Range-Finding Study for Immunological Evaluation of Glycidol in Female B6C3F1 Mice (CASRN: 556-52-5) 1992 Immunotoxicity
IMM91019 N/A NTP Report on the Immunotoxicity of Glycidol (CAS No. 556-52-5) in Female B6C3F1 Mice (gavage studies) 1993 Immunotoxicity
IMM20709 N/A NTP Report on the Assessment of Contact Hypersensitivity to Heptachlor in Female BALB/c Mice (CASRN: 76-44-8) 2010 Immunotoxicity
IMM84001 N/A NTP Report on the Immunotoxicity of 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin (HCDD) (CAS No. 57653-85-7)in Female B6C3F1 Mice 1985 Immunotoxicity
IMM94009 N/A NTP Report on the Dose Range-Finding Study for the Immunotoxicity Evaluation of Indium Arsenide (CAS No. 1303-11-3) in Female B6C3F1 Mice N/A Immunotoxicity
IMM20003 N/A NTP Dose Range-Finding Report - Immunological Evaluation of Indium Phosphate in Female B6C3F1 Mice (CASRN: 20694-56-8) 1992 Immunotoxicity
I05051 N/A NTP Report on the Assessment of Contact Hypersensitivity to 1-Butyl-1-Methylpyrrolidinium Chloride in Female BALB/c Mice (CASRN: 479500-35-1) 2011 Immunotoxicity
I07018 N/A NTP Report on the Assessment of Contact Hypersensitivity to 1-Ethyl-3-Methylimidazolium Chloride in Female BALB/c Mice (CASRN: 65039-09-0) 2010 Immunotoxicity
I05052 N/A NTP Report on the Assessment of Contact Hypersensitivity to N-Butyl-Pyridinium Chloride in Female BALB/c Mice (CASRN: 1124-64-7) 2011 Immunotoxicity
I05050 N/A NTP Report on the Assessment of Contact Hypersensitivity to 1-Butyl-3-Methylimidazolium Chloride in Female BALB/c Mice (CASRN: 79917-90-1) 2010 Immunotoxicity
IMM87038 N/A NTP Assessment of Contact Hypersensitivity to Isobutyraldehyde Fluid (CAS No. 78-84-2) in Female B6C3F1 Mice 1990 Immunotoxicity
IMM20702 N/A NTP Report on the Assessment of Contact Hypersensitivity to Iso-E Super in Female BALB/c Mice (CASRN: 54464-57-2) 2010 Immunotoxicity
IMM90001 N/A NTP Report on the Immunotoxicity of Isophorone Diisocyanate (CAS No. 4098-71-9) in Female B6C3F1 Mice (contact hypersensitivity studies) N/A Immunotoxicity
IMM96002 N/A NTP Report on the Immunotoxicity of Isonicotinic acid hydrazide (Isoniazid) (CAS No.54-85-3) in Female B6C3F1 Mice (14-day study) 1995 Immunotoxicity
IMM96012 N/A NTP Report on the Immunotoxicity of Isonicotinic acid hydrazide (Isoniazid) (CAS No.54-85-3) in Female B6C3F1 Mice (28-day study) 1996 Immunotoxicity
IMM90027 N/A NTP Report on the Assessment of Contact Hypersensitivity to Isophorone Diisocyanate in Female Albino in Hartley Strain Guinea Pigs (CASRN: 4098-71-9) 1990 Immunotoxicity
IMM97008 N/A NTP Range-Finding Report - Immunotoxicity of Itraconazole in Female B6C3F1 Mice (CASRN: 84625-61-6) 2006 Immunotoxicity
IMM85001 N/A NTP Report on the Immunotoxicity of Lithium Carbonate in Female B6C3F1 Mice (CAS No. 554-13-2) 1986 Immunotoxicity
IMM20503 N/A NTP Range-Finding Report - Immunotoxicity of Lovastatin in Female B6C3F1 Mice (CASRN: 75330-75-5) 2012 Immunotoxicity
IMM90003 N/A NTP Report on the Immunotoxicity of 2-Mercaptobenzothiazole (CAS No. 149-30-4) in Female B6C3F1 Mice (contact hypersensitivity studies) N/A Immunotoxicity
IMM94005 N/A NTP Report on the Dose Range-Finding Study of the Immunological Evaluation of Methadone Hydrochloride (CAS No. 1095-90-5) in Female B6C3F1 Mice N/A Immunotoxicity
IMM94008 N/A NTP Report on the Immunotoxicity of Methadone Hydrochloride (CAS No. 1095-90-5) in Female B6C3F1 Mice 1994 Immunotoxicity
MG96004 N/A NTP Assessment of the Immunotoxicity of Methoxychlor (Endocrine Disruptor) (CAS No. 72-43-5) in Male and Female Sprague-Dawley Rats N/A Immunotoxicity
IMM91028 N/A NTP Report on the Assessment of Contact Hypersensitivity to 2-Methoxyethanol (EGMME) in Female B6C3F1 Mice (CASRN: 109-86-4) 1991 Immunotoxicity
IMM98007 N/A NTP Report on the Assessment of Contact Hypersensitivity to 2-Methoxy-4-nitroaniline in Female BALB/c Mice (CASRN: 97-52-9) 2011 Immunotoxicity
IMM98008 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dinitrochlorobenzene (CASRN: 97-00-7), Potassium Dichromate (CASRN: 7778-50-9) and Methyl Salicylate (CASRN: 119-36-8) in BALB/c Female Mice 1997 Immunotoxicity
IMM98006 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dinitrochlorobenzene (CASRN: 97-00-7), Potassium Dichromate (CASRN: 7778-50-9) and Methyl Salicylate (CASRN: 119-36-8) in BALB/c Female Mice 1997 Immunotoxicity
IMM98007 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dinitrochlorobenzene (CASRN: 97-00-7), Potassium Dichromate (CASRN: 7778-50-9) and Methyl Salicylate (CASRN: 119-36-8) in BALB/c Female Mice 1997 Immunotoxicity
IMM20005 N/A NTP Report on the Dose Range-Finding Study for the Immunological Evaluation of Morphine Sulfate (CAS No. 64-31-3) in Female B6C3F1 Mice 1992 Immunotoxicity
IMM92044 N/A NTP Report on the Immunotoxicity of Morphine Sulfate in Female B6C3F1 Mice (CAS No. 61-34-3) 1992 Immunotoxicity
IMM20603 N/A NTP Report on the Assessment of Contact Hypersensitivity to 1,5-Naphthalene-Diisocyanate in Female BALB/c Mice (CASRN: 3173-72-6) 2011 Immunotoxicity
IMM20304 N/A NTP Report on the Immunotoxicity of Nevirapine in Female B6C3F1/N Mice (CASRN: 129618-40-2) 2012 Immunotoxicity
IMM20305 N/A NTP Report on the Developmental Immunotoxicology Evaluation of Nevirapine in Female B6C3F1 Mice (CASRN: 129618-40-2) 2012 Immunotoxicity
IMM20604 N/A NTP Range-Finding Report: Immunotoxicity of Nelfinavir Mesylate in Female B6C3F1/N Mice (CASRN: 159989-65-8) 2012 Immunotoxicity
IMM90011 N/A NTP Report on the Immunotoxicity of Nitrofurazone (CAS No. 59-87-0) in Female B6C3F1 Mice (immune modulation studies) N/A Immunotoxicity
IMM95002 N/A NTP Report on the Immunotoxicity of meta-Nitrotoluene In Female B6C3F1 Mice (CASRN: 99-08-1) 1987 Immunotoxicity
MG96003 N/A NTP Report of the Immunotoxicity of Nonylphenol (Endocrine Disruptor) (CAS No. 84852-15-3) in Male and Female Sprague-Dawley Rats N/A Immunotoxicity
IMM87033 N/A NTP Report on the Immunotoxicity of Para-nitrotoluene (CAS No. 99-99-0) in Female B6C3F1 Mice 1987 Immunotoxicity
IMM20505 N/A NTP Report on the Assessment of Contact Hypersensitivity to Norbixin in Female BALB/c Mice (CASRN: 542-40-5) 2009 Immunotoxicity
IMM90004 N/A NTP Report on the Immunotoxicity of Oleic Acid Diethanolamine (CAS No. 13961-86-9) in Female B6C3F1 Mice (contact hypersensitivity studies) N/A Immunotoxicity
IMM90012 N/A NTP Report on the Immunotoxicity of Oxymetholone (CAS No. 434-07-1) in male B6C3F1 Mice (immune modulation studies) 1990 Immunotoxicity
IMM96010 N/A NTP Report on the Immunotoxicity of Patulin (CAS No. 149-29-1) in Female B6C3F1 Mice (immunosuppression studies) 1997 Immunotoxicity
IMM96016 N/A NTP Report on the Dose Range-Finding Study for the Immunotoxicity Evaluation of Patulin (CAS No. 149-29-1) in Female Fischer Rats 2004 Immunotoxicity
I10327 N/A NTP Range-Finding Report Immunotoxicity of 1,2,3,7,8-Pentabromodibenzofuran and 1,2,3,7,8-Pentachlorodibenzofuran (CASRN: 107555-93-1 and 57117-41-6) 2012 Immunotoxicity
I88217 N/A NTP Range-Finding Report Immunotoxicity of 1,2,3,7,8-Pentabromodibenzofuran and 1,2,3,7,8-Pentachlorodibenzofuran (CASRN: 107555-93-1 and 57117-41-6) 2012 Immunotoxicity
I10328 N/A NTP Range-Finding Report - Immunotoxicity of 2,3,4,7,8-Pentabromodibenzofuran and 2,3,4,7,8-Pentachlorodibenzofuran (CASRN: 13116-92-2 and 57117-31-4) 2012 Immunotoxicity
I92005 N/A NTP Range-Finding Report - Immunotoxicity of 2,3,4,7,8-Pentabromodibenzofuran and 2,3,4,7,8-Pentachlorodibenzofuran (CASRN: 13116-92-2 and 57117-31-4) 2012 Immunotoxicity
IMM95011 N/A NTP Report on the Assessment of Contact Hypersensitivity to Pentaerythritol Triacrylate Mixture in BALB/c Female Mice (CASRN: 3524-68-3) 1997 Immunotoxicity
IMM88036 N/A NTP Report on the Immunotoxicity of Pentamidine Isethionate in Female C57Bl/6 Mice (CAS No. 140-64-7) 1989 Immunotoxicity
I08010 N/A NTP Report on the Assessment of Contact Hypersensitivity to 2,3-Pentanedione in Female BALB/c Mice (CASRN: 600-14-6) 2011 Immunotoxicity
I92006 N/A NTP Range-Finding Report: Immunotoxicity of Perfluoro-N-decanoic acid in Female Harlan Sprague Dawley Rats (CASRN: 335-76-2) 2012 Immunotoxicity
IMM20203 N/A NTP Report on the Immunotoxicity of Phenol in Female B6C3F1 Mice (CASRN: 108-95-2) 2012 Immunotoxicity
IMM90006 N/A NTP Report on the Immunotoxicity of Polydimethylsiloxane (CAS No. 9016-00-6 or 63394-02-5) in Female B6C3F1 Mice (contact hypersensitivity studies) N/A Immunotoxicity
IMM89051 N/A NTP Report on the Immunotoxicity of Polydimethylsiloxane Rubber (CAS No. 9016-00-6) in Female B6C3F1 Mice (10-Day exposure) N/A Immunotoxicity
IMM98008 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dinitrochlorobenzene (CASRN: 97-00-7), Potassium Dichromate (CASRN: 7778-50-9) and Methyl Salicylate (CASRN: 119-36-8) in BALB/c Female Mice 1997 Immunotoxicity
IMM98006 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dinitrochlorobenzene (CASRN: 97-00-7), Potassium Dichromate (CASRN: 7778-50-9) and Methyl Salicylate (CASRN: 119-36-8) in BALB/c Female Mice 1997 Immunotoxicity
IMM98007 N/A NTP Report on the Assessment of Contact Hypersensitivity to Dinitrochlorobenzene (CASRN: 97-00-7), Potassium Dichromate (CASRN: 7778-50-9) and Methyl Salicylate (CASRN: 119-36-8) in BALB/c Female Mice 1997 Immunotoxicity
IMM94007 N/A NTP Report on the Dose Range-Finding Study for the Immunotoxicity Evaluation of Pyrimethamine and AZT in Female B6C3F1 Mice N/A Immunotoxicity
IMM96013 N/A NTP Report on the Immunotoxicity of Pyrimethamine and AZT in Female B6C3F1 Mice 1996 Immunotoxicity
IMM20103 N/A NTP Report on the Assessment of Contact Hypersensitivity to Pyrogallol in BALB/c Female Mice (CASRN: 87-66-1) 2006 Immunotoxicity
IMM90010 N/A NTP Report on the Immunotoxicity of Ribavirin (CAS No. 36791-04-5) in Female C57BL/6 Mice (immune modulation studies) 1989 Immunotoxicity
IMM20010 N/A NTP Report on the Assessment of Contact Hypersensitivity to Rifamycin-SV in BALB/c Female Mice (CASRN: 14897-39-3) 2006 Immunotoxicity
I01090 N/A NTP Report on the Assessment of the Ability of trans-Resveratrol to Modulate Type 1 Diabetes in Female Non-Obese Diabetic (NOD/MrkTac) Mice (CASRN: 501-36-0) 2012 Immunotoxicity
IMM20704 N/A NTP Range-Finding Report - Immunotoxicity of trans-Resveratrol in Male B6C3F1 Mice (CASRN: 501-36-0) 2011 Immunotoxicity
IMM97001 N/A NTP Report on the Dose Range-Finding Study for the Immunotoxicity Evaluation of Saquinavir (CAS No. 149845-06-7) in Female B6C3F1 Mice 2004 Immunotoxicity
IMM98009 N/A NTP Report on the Immunotoxicity Evaluation of Saquinavir (CAS No. 149845-06-7) in Female B6C3F1 Mice 2004 Immunotoxicity
IMM89050 N/A NTP Report on the Immunotoxicity of Silicone (CAS No. 9016-00-6) in Female B6C3F1 Mice (180-Day exposure) N/A Immunotoxicity
IMM89051 N/A NTP Report on the Immunotoxicity of Silicone (CAS No. 9016-00-6) in Female B6C3F1 Mice (10-Day exposure) N/A Immunotoxicity
IMM94004 N/A NTP Report on the Dose Range-Finding Study for the Immunotoxicity Evaluation of Sodium Arsenite (CAS No. 7784-46-5) in Female B6C3F1 Mice 1994 Immunotoxicity
IMM98004 N/A Final Range-Finding Report: Immunotoxicity of Sodium Bromate (CAS No. 7789-38-0) in Female B6C3F1 Mice N/A Immunotoxicity
IMM98005 N/A NTP Immunotoxicity Range-finding Report of the Water Disinfection Byproduct, Sodium Chlorite (CAS No. 7758-19-2) in Female B6C3F1 Mice N/A Immunotoxicity
IMM20202 N/A NTP Range-Finding Report - Immunotoxicity of Hexavalent Chromium (Sodium Dichromate Dihyrate) in Female F344 Rats (CASRN: 7789-12-0) 2007 Immunotoxicity
IMM20202 N/A NTP Range-Finding Report - Immunotoxicity of Hexavalent Chromium (Sodium Dichromate Dihyrate) in Female Sprague Dawley Rats (CASRN: 7789-12-0) 2007 Immunotoxicity
IMM99002 N/A NTP Report on the Assessment of Contact Hypersensitivity to Sodium Metasilicate in BALB/c Female Mice (CASRN: 6834-92-0) 2000 Immunotoxicity
I03038 N/A NTP Range-Finding Report: Immunotoxicity of Sodium Tungstate Dihydrate in Female B6C3F1/N Mice (CASRN: 10213-10-2) 2012 Immunotoxicity
I05059 N/A NTP Report on the Immunotoxicity evaluations of samples from male and female Harlan Sprague Dawley rats exposed to specular hematite by inhalation for up to 39 weeks 2012 Immunotoxicity
IMM90017 N/A NTP Report on the Immunotoxicity of Succinyl Concanavalin A (SCA) (CAS No. 55128-23-9) in Female C57BL/6 Mice (immune modulation studies) 1991 Immunotoxicity
IMM87036 N/A NTP Report on the Immunotoxicity of Tertiary Butylhydroquinone (CAS No. 1948-33-0) in Female B6C3F1 Mice (gavage studies) N/A Immunotoxicity
I10326 N/A NTP Range-Finding Report: Immunotoxicity of 2,3,7,8-Tetrabromodibenzofuran and 2,3,7,8-Tetrachlorodibenzofuran (CASRN: 67733-57-7 and 51207-31-9) 2012 Immunotoxicity
I10037 N/A NTP Range-Finding Report: Immunotoxicity of 2,3,7,8-Tetrabromodibenzofuran and 2,3,7,8-Tetrachlorodibenzofuran (CASRN: 67733-57-7 and 51207-31-9) 2012 Immunotoxicity
I88486 N/A NTP Range-Finding Report: Immunotoxicity of 3,3',4,4'-Tetrachloroazobenzene in Female Sprague Dawley Rats (CASRN: 14047-09-7) 2012 Immunotoxicity
I10157 N/A NTP Range-Finding Report: Immunotoxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN: 1746-01-6) 2012 Immunotoxicity
IMM20009 N/A NTP Evaluation of Tetraethyl Lead Immunology (CAS No. 78-00-2) 1986 Immunotoxicity
IMM97011 N/A NTP Report on the Dose Range-Finding Study for the Immunotoxicity Evaluation of Thalidomide (CAS No. 50-35-1) in Female B6C3F1 Mice 1997 Immunotoxicity
IMM96006 N/A NTP Report on the Immunotoxicity of Thalidomide (CAS No. 50-35-1) in Female B6C3F1 Mice (immunosuppression studies) 1989 Immunotoxicity
I10324 N/A NTP Range-Finding Report Immunotoxicity of 2,3,7-Tribromodibenzo-p-dioxin and 2,3-Dibromo-7,8-dichlorodibenzo-p-dioxin (CASRN: 51974-40-4 and 50585-40-5) 2012 Immunotoxicity
I10325 N/A NTP Range-Finding Report Immunotoxicity of 2,3,7-Tribromodibenzo-p-dioxin and 2,3-Dibromo-7,8-dichlorodibenzo-p-dioxin (CASRN: 51974-40-4 and 50585-40-5) 2012 Immunotoxicity
IMM96007 N/A NTP Report on the Immunotoxicity of Trichloroethylene (CAS No. 79-01-6) in Female Brown-Norway Rats (autoimmunity studies) 1997 Immunotoxicity
IMM98010 N/A NTP Report on the Dose Range-Finding Study for Immunological Evaluation Trichloroethylene (CAS No. 79-01-6) in Female B6C3F1 Mice (Corn Oil) N/A Immunotoxicity
IMM20006 N/A NTP Dose Range-Finding Study for Immunological Evaluation of Trichloroethylene in 10% Emulphor in Female B6C3F1 Mice (CASRN: 79-01-6) 1992 Immunotoxicity
IMM20008 N/A NTP Dose Range-Finding Study for Immunological Evaluation of Trichloroethylene in 10% Emulphor in Male CD-1 Mice (CASRN: 79-01-6) 1992 Immunotoxicity
IMM97004 N/A NTP Report on the Assessment of Contact Hypersensitivity to 2,4,5-Trichlorophenoxyacetic Acid in Female B6C3F1 Mice (CASRN: 93-76-5) 1997 Immunotoxicity
IMM90005 N/A NTP Report on the Immunotoxicity of Triethanolamine (CAS No. 102-71-6) in Female B6C3F1 Mice (contact hypersensitivity studies) N/A Immunotoxicity
IMM95008 N/A NTP Report on the Assessment of Contact Hypersensitivity to 2-Ethyl-2-(Hydroxymethyl)-1,3-Propanediol Triacrylate (Trimethylolpropane Triacrylate) in Female B6C3F1 Mice (CASRN: 15625-89-5) 1995 Immunotoxicity
IMM97003 N/A NTP Report on the Assessment of Contact Hypersensitivity to Trimethylolpropane Triacrylate Mixture in Female BALB/c Mice (CASRN: 15625-89-5) 1995 Immunotoxicity
IMM91032 N/A NTP Report on the Assessment of Contact Hypersensitivity to 2,4,7-Trinitrofluoren-9-one in Female B6C3F1 Mice (CASRN: 129-79-3) 1991 Immunotoxicity
IMM92060 N/A NTP Report on the Assessment of Contact Hypersensitivity to Triphenyl Phosphate in Female B6C3F1 Mice (CASRN: 115-86-6) 1992 Immunotoxicity