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Reproductive Toxicity Study Abstracts

The following list of abstracts represents studies conducted by NTP beginning in 1985. These studies have not been evaluated by the levels of evidence for reproductive criteria established by NTP in March 2009. Because this list may not be totally comprehensive, contact cdm@niehs.nih.gov (or use our contact form) to inquire about other studies.


A | B | C | D | E | F | G | H | I | J | K | L | M | N | O | P | Q | R | S | T | U | V | W | X | Y | Z


A

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Acetaminophen Acetaminophen : (CAS # 103-90-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed
Acrylamide Acrylamide (CAS No. 79-06-1): Reproductive Toxicity in CD-1 Swiss Mice
Alternate Task 3 Design Alternate Task 3 Design in CD Sprague-Dawley Rats
9-Aminoacridine hydrochloride Reproduction and Fertility Assessment of 9-Aminoacridine Hydrochloride (CAS# 134-50-9) in CD-1 Mice When Administered in Feed
Azidothymidine (AZT) Azidothymidine(AZT) CAS# 30516-87-1: Multigenerational Reproductive Assessment by Continuous Breeding When Administered to Swiss CD-1® Mice by Gavage
Azidothymidine (AZT) and Methadone HCl Reproductive/Developmental/General Toxicity Study of 3'-Azido-3'-Deoxythymidine (AZT)/Methadone Hydrochloride Combinations in CD-1 Mice

B

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Bisphenol A Bisphenol A: (CAS No. 80-05-7) Reproduction and Fertility Assessment in CD-1 Mice When Administered Via Subcutaneous Silastic® Implants
Bisphenol A Bisphenol A: (CAS No. 80-05-7) Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed
Boric Acid Reproductive Toxicity of Boric Acid (CAS No. 10043-35-3) in CD-1 Swiss Mice
Bromoform Bromoform (Tribromomethane) (CAS No. 75-25-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage
2, 2-bis(bromomethyl)-1,3-propanediol 2, 2-bis(bromomethyl)-1,3-propanediol (CAS #3296-90-0): Reproduction and Fertility Assessment in CD-1 Mice When Administered In Feed

C

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Caffeine Reproductive Toxicity of Caffeine (CAS No: 58-08-2) Administered by Gavage to Sprague-Dawley Rats
Caffeine Caffeine (CAS #58-08-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water
Caffeine Caffeine (CAS #58-08-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Carisoprodol Reproductive Toxicity of Carisoprodol (CAS No. 78-44-4) in CD-1 Swiss Mice
Chemical Mixture - Drinking Water Contaminants Reproductive Toxicity of a Chemical Mixture (NTP CAS No. CHEMMIXH2O) in CD-1 Swiss Mice
Chemical Mixture - Drinking Water Contaminants Reproductive Toxicity of a Mixture of Ground Water Contaminants (CAS No. CHEMMIXH2O) in Sprague-Dawley Rats
Chloroform Chloroform (CAS No. 67-66-3): Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage
2-Chloronitrobenzene Reproductive Toxicity of 2-Chloronitrobenzene (CAS No. 88-73-3) in CD-1 Swiss Mice
4-Chloronitrobenzene Reproductive Toxicity of 4-Chloronitrobenzene (CAS No. 100-00-5) in CD-1 Swiss Mice
1-Chloro-2-propanol 1-Chloro-2-propanol (CAS No. 127-00-4): Reproduction and Fertility Assessment In CD Sprague-Dawley Rats Via Drinking Water
Ortho-Cresol Reproductive Toxicity of Ortho-Cresol (OCRE), CAS No. 95-48-7, in CD-1 Swiss Mice
Meta-/Para-Cresol Reproductive Toxicity of Meta-/Para-Cresol (MPCRE) (CAS No. 1319-77-3) in CD-1 Swiss Mice

D

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Diazepam Reproductive Toxicity of Diazepam (CAS No. 439-14-5) in CD Sprague-Dawley Rats
Dibromochloropropane Dibromochloropropane (CAS #96-12-8): Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage
Dibutyl Phthalate DiButyl Phthalate (CAS No. 84-74-2): Multigenerational Reproductive Assessment by Continuous Breeding When Administered to Sprague-Dawley Rats in the Diet
Diethylhexylphthalate Multigenerational Reproductive Assessment by Continuous Breeding when Diethylhexylphthalate (CAS 117-81-7) was Administered to Sprague Dawley Rats in the Diet
Diethylene Glycol Diethylene Glycol (CAS #111-46-6): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water
Diethylene glycol monoethyl ether Reproductive and Fertility Assessment of Diethylene Glycol Monoethyl Ether (CAS No. 111-90-0) in CD-1 Mice when Administered in Drinking Water
Diethyl Phthalate Diethyl Phthalate (CAS #84-66-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed
Diethylhexyl Phthalate Diethylhexyl Phthalate (CAS No. 117-81-7): Reproduction & Fertility Evaluation in F344 Rats Exposed During Gestation
Diethylstilbestrol (EHRT) Diethylstilbestrol (CAS #56-53-1): Fertility Assessment in CD-1 Mice When Administered in Feed
trans-Diethylstilbestrol (DES) Reproductive and Fertility Assessment of Trans-Diethylstilbestrol (DES) (CAS No. 56-53-1) in CD-1 Mice When Administered in the Feed
N,N-Dimethyl Formamide Reproductive Toxicity of N,N-Dimethyl Formamide (CAS No. 68-12-2) in CD-1 Swiss Mice
Di(n-butyl) Phthalate Di(n-butyl) Phthalate (CAS No. 84-74-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Feed
Di(n-butyl) Phthalate Reproductive Toxicity of Di-N-Butyl Phthalate (CAS No. 84-74-2) in Sprague-Dawley Rats
Di-(n-hexyl)phthalate Di-(n-hexyl)phthalate (CAS #84-75-3): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed
Di-N-Propylphthalate Di-N-Propylphthalate (CAS #131-16-8): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed
Dioctyl Phthalate Dioctyl Phthalate (CAS #117-84-0): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed

E

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Elmiron Reproductive Toxicity of Elmiron (CAS No. 37319-17-8) Administered by Gavage to Sprague-Dawley Rats
Ethanol Ethanol (CAS # 64-17-5): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Ethoxyacetic Acid Ethoxyacetic Acid (CAS #627-03-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Ethylene Glycol Ethylene Glycol (CAS #107-21-1): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Ethylene Glycol Ethylene Glycol (CAS #107-21-1): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Ethylene Glycol Monobutyl Ether Ethylene Glycol Monobutyl Ether (CAS #111-76-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Ethylene Glycol Monoethyl Ether Ethylene Glycol Monoethyl Ether (CAS No. 110-80-5): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Water
Ethylene Glycol Monoethyl Ether Acetate Ethylene Glycol Monoethyl Ether Acetate (CAS #111-15-9): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Ethylene Glycol Monomethyl Ether Ethylene Glycol Monomethyl Ether (CAS #109-86-4): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Wate
Ethylene Glycol Monomethyl Ether Ethylene Glycol Monomethyl Ether (CAS #109-86-4): Reproduction and Fertility Assessment in C57Bl/6 Mice When Administered in Drinking Water
Ethylene Glycol Monomethyl Ether Ethylene Glycol Monomethyl Ether (CAS #109-86-4): Reproduction and Fertility Assessment in C3H Mice When Administered in Drinking Water
Ethylene Glycol Monomethyl Ether Reproductive Toxicity of Ethylene Glycol Monomethyl Ether (CAS #109-86-4) in Sprague-Dawley Rats, Litter Five
Ethylene Glycol Monomethyl Ether Reproductive Toxicity of Ethylene Glycol Monomethyl Ether (CAS No. 109-86-4) in Sprague-Dawley Rats, Litter Two
Ethylene Glycol Monomethyl Ether Ethylene Glycol Monomethyl Ether (CAS #109-86-4): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Ethylene Glycol Monomethyl Ether Ethylene Glycol Monomethyl Ether: (CAS# 109-86-4) Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Ethylene Glycol Monophenyl Ether Reproduction and Fertility Assessment of Ethylene Glycol Monophenyl Ether (CAS #122-99-6) in CD-1 Mice When Administered in Feed

F

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Feed Restriction (Mouse Study no. 1) Reproductive Toxicity of Dietary Restriction (NTP CAS No. FEED RESTRICT) in CD-1 Swiss Mice
Feed Restriction (Mouse Study no. 2) Reproductive Toxicity Associated with Feed Restriction (CAS No. FEEDRESTRICT) in CD-1 Swiss Mice
Feed Restriction Reproductive Toxicity Associated with Feed Restriction (CAS No. FEEDRESTRICT) in Sprague-Dawley Rats
Formamide Reproductive Toxicity of Formamide (FORM) (CAS No. 75-12-7) in CD-1 Swiss Mice

H

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
2-Hydroxy-4-Methoxybenzophenone 2-Hydroxy-4-Methoxybenzophenone (CAS No. 131-57-7): Reproductive Toxicity in CD-1 Swiss Mice; Dose 1.25, 2.5 & 5% in Feed

I

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Isoeugenol Isoeugenol (CAS No. 97-54-1): Reproductive Assessment by Continuous Breeding when Administered to Sprague-Dawley Rats by Gavage

L

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Lead (2+) Acetate Lead Acetate Trihydrate (CAS #301-04-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water
Lead (2+) Acetate Lead Acetate Trihydrate (CAS # 301-04-2): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Lead Acetate Trihydrate Reproductive Toxicity of in Lead Acetate Trihydrate (CAS #6080-56-4) in Sprague-Dawley Rats

M

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Methacrylonitrile Reproductive Toxicity of Methacrylonitrile (CAS No. 126-98-7) Administered in Diet to Sprague-Dawley Rats
Methoxyacetic Acid Methoxyacetic Acid (CAS #625-45-6): Reproductive and Fertility Assessment in CD-1 Mice When Administered in the Drinking Water
Methacrylamide Reproductive Toxicity of Methacrylamide (CAS # 79-39-0) in CD-1 Mice Administered in Drinking Water
N,N'-Methylenebisacrylamide Reproductive Toxicity of N,N'-Methylenebisacrylamide (CAS# 110-26-9) in CD-1 Swiss Mice
N-Methylolacrylamide Reproductive Toxicity of N-Methylolacrylamide (CAS No. 924-42-5) in CD-1 Swiss Mice
Methylphenidate Hydrochloride Methylphenidate Hydrochloride (CAS No. 298-59-9): Reproduction and Fertility Assessment in CD-1 Mice When Administered In Feed
Methyl Salicylate Methyl Salicylate, CAS #119-36-8): Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage
Methyl Salicylate Methyl Salicylate (CAS 119-36-8): Reproduction and Fertility Assessment in CD-1 Mice When Administered by Gavage

N

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
m-Nitrobenzoic Acid m-Nitrobenzoic Acid (CAS #121-92-6): Reproductive Toxicity in CD-1 Swiss Mice
para-Nitrobenzoic Acid Reproductive Toxicity of para-Nitrobenzoic Acid (CAS No. 62-23-7) in CD-1 Swiss Mice
Nitrofurantoin Nitrofurantoin (CAS No. 67-20-9): Reproduction and Fertility Assessment in CD-1 Mice When Administered via Feed
Nitrofurazone Reproductive Toxicity of Nitrofurazone (CAS No. 59-87-0) in CD-1 Swiss Mice
Nonylphenol, branched (NP), Nonylphenol: Multigenerational Reproductive Effects in Sprague-Dawley Rats when Exposed to Nonylphenol (CASRN: 84852-15-3) in the Diet

O

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Oxalic Acid Oxalic Acid (CAS #144-62-7): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water

P

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Di-N-Pentylphthalate Di-N-Pentylphthalate (CAS# 131-18-0): Reproduction and Fertility Assessment in CD-1 Mice When Administered In Feed
Pesticide/Fertilizer Mixture II Reproductive Toxicity of Pesticide/Fertilizer Mixture II (CAS No. PESTFERTMIX2) in CD-1 Swiss Mice
Pesticide/Fertilizer Mixture III (Iowa) Reproductive Toxicity of Iowa Pesticide/Fertilizer Mixture (CAS No. PESTFERTMIX3) in CD-1 Swiss Mice
Phenolphthalein Reproductive Toxicity of Phenolphthalein (CAS No. 77-09-8) in CD-1 Swiss Mice
Potassium Dichromate (Hexavalent) Reproductive Toxicity (Testicular) of Potassium Dichromate (Hexavalent) (CAS 7778-50-9) Administered in Diet to BALB/c Mice
Potassium Dichromate (Hexavalent) Reproductive Toxicity of Potassium Dichromate (Hexavalent) (CAS 7778-50-9) Administered in Diet to SD Rats
Potassium Dichromate (Hexavalent) Reproductive Toxicity of Potassium Dichromate (Hexavalent) (CAS 7778-50-9) Administered in Diet to BALB/c Mice
Primaclone Reproductive Toxicity of Primaclone (CAS No. 125-33-7) in CD-1 Swiss Mice
Pubertal Toxicity Study Pubertal Toxicity Study of Vinclozolin (Cas No. 50471-44-8), Flutamide (Cas No. 13311-84-7)and Phenobarbital (Cas No. 50-06-6)in Male Sprague Dawley Rats and Methoxychlor (Cas No. 72-43-5), Ethinyl Estradiol (Cas No. 57-63-6)and Phenobarbital in Female Sprague Dawley Rats when Administered in Corn Oil by Oral Gavage
Propylene Glycol Propylene Glycol (CAS No. 57-55-6): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Propantheline Bromide Propantheline Bromide (CAS# 50-34-0): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed
Propylene Glycol Monomethyl Ether Propylene Glycol Monomethyl Ether (CAS #107-98): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Propylthiouracil Two-Generation Reproduction Toxicity Study of Propylthiouracil (CAS#51-52-5) when Administered to Sprague-Dawley Rats in the Drinking Water

S

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Salicylazosulfapyridine Reproductive Toxicity of Salicylazosulfapyridine (CAS No. 599-79-1) in CD Sprague-Dawley Rats
Sodium Nitrite Reproductive Toxicity of Sodium Nitrite (CAS No. 7632-00-0) in CD-1 Swiss Mice
Sodium Saccharin Sodium Saccharin (CAS # 128-44-9): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Sulfamethazine Sulfamethazine (CAS #57-68-1): Reproduction and Fertility Assessment in CD-1 Mice When Administered via the Diet

T

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
Tamoxifen Citrate Reproductive Toxicity of Tamoxifen Citrate (CAS No. 54965-24-1) Administered by Gavage to Sprague-Dawley Rats
3,3',4,4'-Tetrachloroazobenzene (TCAB) Abstract for NTP Study of Reproductive Assessment by Continuous Breeding when 3,3',4,4'-Tetrachloroazobenzene (TCAB) (CASRN 14047-09-7) was Administered to Sprague Dawley Rats by Oral Gavage
1,2,4,5-Tetrachlorobenzene Reproductive Toxicity of 1,2,4,5-Tetrachlorobenzene (CAS No. 95-94-3) in CD-1 Swiss Mice
Theobromine Reproduction and Fertility Assessment of Theobromine (CAS No. 83-67-0) in CD-1 Mice When Administered in Feed
Theophylline Theophylline (CAS # 58-55-9): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water/Feed
Thiophenol II Reproductive Toxicity of Thiophenol II (CAS No: 108-98-5) Administered by Gavage to Sprague-Dawley Rats
Trichloroethylene Trichloroethylene (CAS # 79-01-6): Reproduction and Fertility Assessment in F344 Rats When Administered in Feed
Trichloroethylene Trichloroethylene (CAS # 79-01-6): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Feed
Triethylene Glycol Reproductive and Fertility Assessment of Triethylene Glycol (CAS #112-27-6) in CD-1 Mice when Administered in Drinking Water
Triethylene Glycol Diacetate Triethylene Glycol Diacetate (CAS #111-21-7): Reproduction and Fertility Assessment in CD-1 Mice When Administered in Drinking Water
Triethylene Glycol Dimethyl Ether Reproductive and Fertility Assessment of Triethylene Glycol Dimethyl Ether (CAS #112-49-2) in CD-1 Mice when Administered in Drinking Water
1,2,3-Trichloropropane Reproductive Toxicity of 1,2,3-Trichloropropane (CAS No. 96-18-4) Administered by Gavage in CD-1 Swiss Mice
Tris(2-chloroethyl)phosphate Reproductive Toxicity of Tris(2-chloroethyl)phosphate (CAS No. 115-96-8) in CD-1 Swiss Mice

V

Listing of Reproductive Toxicity Study Abstracts
Chemical Name Report Title
4-Vinylcyclohexene Reproductive Toxicity of 4-Vinylcyclohexene (CAS No. 100-40-3) in CD-1 Swiss Mice