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Abstract for RACB88076

2-Hydroxy-4-Methoxybenzophenone: Reproductive Toxicity in CD-1 Swiss Mice; Dose 1.25, 2.5 & 5% in Feed

CASRN: 131-57-7
Chemical Formula: C14H12O3
Molecular Weight: 228.247
Report Date: December 1990

Abstract

The following abstract presents results of a study conducted by a contract laboratory for the National Toxicology Program. The findings were not evaluated in accordance with the levels of evidence for reproductive or developmental criteria established by NTP in March 2009. The findings and conclusions for this study should not be construed to represent the views of NTP or the U.S. Government.

2-Hydroxy-4-methoxybenzophenone, (HMBP), a common ingredient in sunscreens and tanning agents, was tested for its effects on fertility and reproduction in Swiss CD-1 mice according to the Continuous Breeding protocol. It was administered via feed. Based on results of a dose-finding study, 1.25, 2.5, and 5.0% (w/w) were chosen to investigate effects on fertility and reproduction. Male and female mice were continuously exposed for a 7-day precohabitation and a 98- day cohabitation period (Task 2). The feed consumption in 2.5 and 5.0% groups was consistently higher but the F0 body weights were consistently lower. These findings suggest that HMBP may be adversely affecting metabolism or the digestive process in Swiss mice. In the 2.5 and 5.0% HMBP groups, the number of live pups per litter was significantly reduced. The F1 generation from control, 2.5 and 5.0% groups were weaned for second generation studies. During lactation and nursing of F1 pups, pup survival was significantly below the control value in the 2.5 and 5.0% groups. HMBP had minimal effects on fertility in the F1 generation but F2 pup weights were significantly reduced.

Based on the results of the present study, it is concluded that HMBP causes systemic toxicity but has minimal effects on fertility and reproduction at these doses.

NTIS# PB91158477