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National Toxicology Program

National Toxicology Program

UPDATE NewsletterUPDATE NewsletterJanuary 2015

NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)

By Catherine Sprankle

NICEATM to Present ICCVAM Communities of Practice Webinar on Reverse Toxicokinetic Models

On behalf of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM), NICEATM and the U.S. Environmental Protection Agency’s National Center for Computational Toxicology (NCCT) will present the first ICCVAM Communities of Practice webinar. The webinar, “Reverse Toxicokinetics: Using In Vitro Data to Estimate Exposures that Could Be Associated with Adverse Effects In Vivo,” will focus on the development and application of reverse toxicokinetic models for extrapolation of high-throughput screening data to in vivo dosimetry. John Wambaugh, Ph.D., physical scientist at NCCT, will provide an overview of the development of reverse toxicokinetic models and Barbara Wetmore, Ph.D., senior research investigator at the Hamner Institutes for Health Sciences, will discuss the consideration of population variability and sensitive subpopulations in the use of these models.

The webinar will be presented on January 27 at 1:00 p.m. Information about the webinar and a link to registration are available at https://ntp.niehs.nih.gov/go/ivive-webinar.

Scoping Document on Thyroid Assays Available

“New Scoping Document on In Vitro and Ex Vivo Assays for the Identification of Modulators of Thyroid Hormone Signalling,” published by the Organisation for Economic Co-operation and Development (OECD), is now available. This document provides recommendations for the development and use of existing in vitro and ex vivo thyroid assays and identifies data gaps that require development of additional tests. The document was developed under the leadership of the OECD Expert Group on Amphibian Testing and the OECD Validation Management Group on Non-Animal Testing (VMG-NA) with contributions from NICEATM scientists. NICEATM Director Warren Casey, Ph.D. is a member of VMG-NA.

The scoping document, along with other OECD documents on endocrine disruptor testing, is available on the OECD website at https://www.oecd.org/chemicalsafety/testing/seriesontestingandassessmenttestingforendocrinedisrupters.htm.

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Director of Office of Policy, Review, and Outreach and Editor-in-Chief: Mary Wolfe | Managing Editor: Anna Lee Mosley